Published in Proteomics Weekly, March 7th, 2005
"Regulation of actin polymerization is essential for cell functioning. Here, we predict a novel phenomenon-the force-driven polymerization of actin filaments mediated by proteins of the formin family. Formins localize to the barbed ends of actin filaments, but, in contrast to the standard capping proteins, allow for actin polymerization in the barbed direction," wrote M.M. Kozlov and colleagues, Tel Aviv University.
"First, we show that the mechanism of such 'leaky capping' can be understood in terms of the elasticity of the...
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