Actin

Actin polymerization analyzed, force-driven mechanism indicated

Published in Proteomics Weekly, March 7th, 2005

According to a study from Israel, processive capping by formin suggests a force-driven mechanism of actin polymerization.

"Regulation of actin polymerization is essential for cell functioning. Here, we predict a novel phenomenon-the force-driven polymerization of actin filaments mediated by proteins of the formin family. Formins localize to the barbed ends of actin filaments, but, in contrast to the standard capping proteins, allow for actin polymerization in the barbed direction," wrote M.M. Kozlov and colleagues, Tel Aviv University.

"First, we show that the mechanism of such 'leaky capping' can be understood in terms of the elasticity of the...

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Source: Proteomics Weekly (2005-03-07)

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