Proteomics Weekly
Susan Hasty, Publisher
Table of Contents . . . April 11th, 2005
Non-Subscriber - Summaries OnlyRelated Areas: Other Issues in Proteomics Weekly | Other Publications
Disease Associations - Staphylococcal arthritis studied, role of fibronectin-binding factors shown
Drug Resistance - Chemokine patterns in meningococcal disease investigated
Matrix Metalloproteinase - Matrix metalloproteinases studied, roles in cardiac allograft rejection revealed
Muscular Dystrophy - Protein 4.1R expression in normal and dystrophic skeletal muscle investigated
Survivin - p21(Ras) studied, influence of survivin in human fibroblasts revealed
Actin - Scinderin analyzed, role as an actin molecular switch determined
Allergy & Immunology - Researchers discover new biomarker for airway inflammation
Alzheimer Disease - Amyloid beta-protein studied, monomer structure and early aggregation clarified
Alzheimer Disease - Chemical decoy shows promise for slowing AD by acting as decoy
Alzheimer Disease - Chemists isolating individual molecules of toxic protein in brain diseases
Alzheimer Disease - New research in the area of Alzheimer disease detailed
Alzheimer Disease - Recent findings in Alzheimer disease described
Amyotrophic Lateral Sclerosis - Researchers publish new studies and findings in the area of amyotrophic lateral sclerosis
Antibiotic Resistance - Staphylococcus aureus studied, prevalence of methicillin-resistance revealed
Antigen Processing - Membrane localization of transporter linked with antigen processing revealed
Alzheimer Disease - Recent findings in Alzheimer disease provide new insights
Antimicrobial Therapy - Research reveals possibility for safe antimicrobial therapy during pregnancy
Antipsychotic Therapy - Chronic effects of clozapine on nucleus accumbens dopamine output clarified
Antisense Technology - Antisense agent AEG 35156 targets the X-linked inhibitor of apoptosis protein
Apoptosis - Glutaredoxin examined role of overexpression in apoptosis defined
Apoptosis - P21(WAF1) examined, physiological effects in fibroblast revealed
Apoptosis - Renal tubular cell apoptosis in glomerulosclerosis studied, factors clarified
Arrhythmia - HIV protease inhibitors may predispose patients to cardiac arrhythmias
Cardiology - Reports add new data to cardiology research
Ataxin - Cellular function of human ataxin-2 examined, integrative approach utilized
Atherosclerosis - Atherogenic effects of alcohol use outweigh benefits in young people
Atherosclerosis - Atherosclerosis studied, epitope mapping of heat-shock proteins reported
Atherosclerosis - Brain research to help in fight against cardiovascular disease
Awards - Myeloma foundation announces 3 winners of targeted therapeutics initiative
Beta Amyloid - Beta-amyloid peptide examined, role in synaptic transmission revealed
Diabetes Pathogenesis - Researchers' work adds to diabetes pathogenesis body of knowledge
Biochemistry - Twin anchor target chip improves accuracy of MALDI-TOF mass spectrometry
Biological Therapies - Enamel matrix derivative inhibited breast cancer cell attachment to bone
Biotechnology - IVC with nano-droplet delivery used to select for DNA-nuclease inhibitors
Biotechnology - Macromolecular interactions in solution assessed via static light scattering
Bipolar Disorder - Research looks beyond lithium to treat psychiatric disease
Blood Brain Barrier - Hypoxia/aglycemia studied, role in expression of occludin and actin clarified
Diabetes Pathogenesis - Studies advance knowledge in diabetes pathogenesis research
Brain Cancer - Bombesin/gastrin-releasing peptide antagonists staunch glioblastoma
Breast Cancer - Enzyme expression ratio is a prognostic indicator in tamoxifen-treated patients
Business & Finance - MedPulser maker reports on "year of transformation"
Business Update - Biotechnology company retains firm for investor relations services
Business Update - Nanotechnology-focused company launches new start-up biotechnology company
Business Update - Technological innovation of Plasmid DNA (pDNA) manufacture announced
Diabetes Therapy - Studies describe new findings in diabetes therapy research
Cancer Diagnostics - Study of genomic DNA leads to new advances
Cancer Immunotherapy - Inhibitory anti-FLT3 antibodies rebuff leukemic induction
Cancer Screening - Screen for leukemia resistance identified mutation pattern for PD166326
Cancer Therapy - Arsenic use endorsed in leukemia therapy
Cancer Therapy - Company reports 67% decrease in metastatic nodules with CTCE-9908
Cancer Therapy - Inhibition of tumor-derived CCL5 also inhibited metastasis of 4T1
Malaria Vaccines - Recent studies add new data to malaria vaccines research
Cancer Therapy - Selective cytotoxicity and telomere damage in leukemia cells by using BIBR1532
Cancer Therapy - The G-quadruplex-interactive molecule BRACO-19 inhibited tumor growth
Cardiac Hypertrophy - New findings in the area of cardiac hypertrophy detailed
Cardiology - AMPK-mediated recruitment of LPL could be response to ensure fatty acid supply
Cardiology - Article provides overview of the composition of the cardiac extracellular matrix
Cardiology - Delayed effects of proctolin and CCAP represent a secondary effect
Oncology - Reports describe recent advances in oncology research
Cardiology - Findings in cardiology provide new insights
Cardiomyocytes - CaMKIIdelta3 induces cardiomyocyte hypertrophy
Cardiomyopathy - Researchers shed light on the mechanisms of lipotoxic cardiomyopathy
Cardiovascular Disease - Role of ceruloplasmin in facilitating, counteracting oxidative stress is central
Cardiovascular Research - Determination of Hcy may improve predictive value of CRP and LDL-cholesterol
Oncology - Researchers provide details of new studies and findings in the area of oncology
Cardiovascular Research - PON1 genotype, Hcy, cholesterol, and age are determinants of HTase activity
Cell Biology - DNA "packaging" linked with cancer
Cell Biology - Liposome finding implies electrical effect on cell development
Cell Biology - Scientists identify new model of NK cell development
Cell Biology - Tiny scaffolding allows stem cells to become working fat cells
Cell Biology - Wnt signals two ways to a healthy gut
Oncology - Researchers publish new studies and findings in the area of oncology
Cell Development - Gene silencing examined, effect on membrane activity and actin clarified
Cell Receptors - N-methyl-D-aspartate receptor studied, effect of neurofilament-light clarified
Cell Regulation - p107 inhibits G1 to S phase progression
Cell Signaling - Ca2+ channels examined, roles of G protein and Shank-binding domain shown
Chlamydia - Studies describe new findings in chlamydia research
Cholesterol - Hippocampal serotonin(1A) receptor studied, role of cholesterol clarified
Virology - Reports advance knowledge in virology research
Chronic Hepatitis C - Suppressor of cytokine signalling-1 may host interferon resistance
Chronic Myelocytic Leukemia - Company obtains orphan drug designation for c-Myb Antisense (LR3001) in CML
Chronic Renal Failure - CRF enhances calcification at atheromatous and atheroma-free sites
Collaborations - Diagnostics company renews cancer research collaboration with Johns Hopkins
Collagens - Keratinocyte migration examined, impairment described
Collagens - Lysyl oxidase isoforms studied, expression in osteoblastic cells defined
Virology - Reports describe recent advances in virology research
Collagens - Wound healing studied, variable impairment in collagenase-resistant mouse shown
Coronary Artery Disease - Response to N-epsilon-Hcy albumin is associated with early-onset CAD
Creutzfeldt-Jakob Disease - FDA committee meeting focused on transmissible spongiform encephalopathies
Cystic Fibrosis - CFTR channel opening studied, mechanism defined
DNA Replication - Bacillus subtilis DnaD and DnaB studied, functional interplay defined
DNA Replication - Accessibility of condensed mitotic chromatin studied
DNA Research - Degree of DNA-repair capacity associated with the risk of human cancers
DNA Vaccines - New findings in the area of DNA vaccines described
Depression Therapy - ECS heightens limbic expression of MAP kinase phosphatases in rats
Developmental Biology - First real-time view of developing neurons reveals surprises
Diabetes - Persistent endothelial dysfunction accounts for poor outcome after AMI
Diabetes Control - Deletion of a protein eliminates hyperglycemia in diabetic mice
Diabetes Control - Leucine reduces the duration of insulin-induced PI 3-kinase activity
Diabetes Control - Muscle-specific Pten deletion may be the key to prevention
Diabetes Control - Researchers describe the mechanisms that regulate GIP release
Diabetes Control - Tannic acid shows promise as an antidiabetic drug
Diabetes Pathogenesis - CRP level may predict Type 2 diabetes
Diabetes Pathogenesis - Researchers provide details of new studies and findings in the area of diabetes pathogenesis
Diabetes Therapy - Beta-cells that secrete GLP-1 have improved glucose-responsiveness
Diabetes Therapy - Findings in diabetes therapy provide new insights
Diabetic Nephropathy - Recent findings illuminate research in diabetic nephropathy
Diagnostic Imaging - Positron emission tomography monitors tumors treated with suicide gene therapy
Diagnostics - Protein-DNA chimeras detect and quantify small numbers of molecules
Diagnostics - UPAR may identify breast cancer patients with a risk for micrometastasis
Disease Associations - Fusobacterium nucleatum studied, role in collagenase production revealed
Disease Associations - Rhizobium etli bacteroids' role against oxidative stress clarified
Disease Associations - S. aureus cidABC and lrgAB operons studied, expression clarified
Disease Associations - Toxoplasma gondii examined, antigen presentation clarified
Disease Associations - Alzheimer disease analyzed, astrocytic binding protein overexpression detected
Disease Associations - Amyloid-mediated neuronal cell death studied, role of polymerization revealed
Disease Associations - Brain natriuretic peptide examined, changes in myocardial necrosis revealed
Disease Associations - EPEC and EHEC adhesion and motility studied, protein dynamics revealed
Disease Associations - Elevated serum type I collagen C-telopeptide in osteoarthritis of the hip
Disease Associations - EspJ analyzed, nature of protein and influence on infection dynamics clarified
Disease Associations - Gingipain-containing virulence complex studied, role in immune evasion shown
Disease Associations - Group B streptococci studied, DNA macrorestriction analysis performed
Disease Associations - IgG antibodies to a beta-glycoprotein I domain studied, role in thrombosis shown
Disease Associations - Neuropeptide substance P studied, role in osteoclast formation revealed
Disease Associations - Outer membrane protein structure of Porphyromonas gingivalis clarified
Disease Associations - Phox peptide antibody examined, nature of interactions with neutrophils shown
Disease Associations - Wiskott-Aldrich syndrome protein studied, role in dendritic-cell homing revealed
Drug Delivery - Research add new data to drug delivery body of knowledge
Drug Development - Computational-directed research agreement on protein kinases announced
Drug Development - Pharmaceutical company obtains worldwide rights to recombinant human bFGF
Effector Proteins - Enteropathogenic Escherichia coli studied, effector proteins' role revealed
Endocrinology - Findings describe new data in endocrinology research
Endocrinology - Glucose transporter examined, distribution and role in injury recovery shown
Endocrinology - Marijuana extracts have endocrine-disrupting effects in rats
Endocrinology - VEGF Trap creates reversible ovarian function inhibition in macaques
Enzymology - Angiotensin-converting enzyme studied, critical role in fertilization revealed
Enzymology - Scientists analyze the function of a hyperthermophilic endoglucanase
Enzymology - cAMP-dependent protein kinase analyzed, allosteric network revealed
Erythropoietin - Erythropoietin expression analyzed, role of neuronal PAS domain protein shown
Finance - Biopharmaceutical company reports 2004 year-end financial results
Finance - Humanized antibodies developer announces improved financial results
Fitness & Wellness - Exercise-induced hippocampal BDNF expression studied, age effect observed
Fitness & Wellness - Growth hormone-dependent markers probed in elite athletes
Follicular Lymphoma Diagnostics - Lack of Bcl-2 expression in follicular lymphoma caused by mutations
Foodborne Illness - Scientists discover that host cell lipids facilitate bacterial movement
Gastric Cancer - COX-2 correlates with F-box protein/Skp2 expression/prognosis in gastric cancer
Gastroenterology - Metastatic lesions flare following primary colorectal cancer removal
Gastroenterology - Researchers publish new studies and findings in the area of gastroenterology
Gene Research - Adipose differentiation-related protein shows clear-cell renal cancer status
Gene Research - Corautus announces contract in connection with GENASIS gene therapy trial
Gene Research - GENE impedance regulates gene expression via generalized mechanisms
Gene Research - Life sciences company signs agreement with MIT to collaborate in RNAi Consortium
Gene Silencing - Overexpressed exportin 5 augments RNA interference
Genetic Disorders - Utility of DNA microarrays in neonatal screening reviewed
Genetic Research - Hematopoietic cells carrying the ribonuclease inhibitor gene hinder melanoma
Genetics - The LPL gene might influence lipid levels, especially TG metabolism
Genetics and Genomics - Drosophila genes with roles in hemocyte function identified
Genomics - Recent findings illuminate research in genomics
Glycosylation - von Willebrand factor domain studied, effect of glycosylation revealed
Growth Factor - Heparin-binding EGF like growth factor studied, characteristics revealed
Growth Factors - Connective tissue growth factor analyzed, effect on kinase receptor revealed
HIV/AIDS Drug Mechanism - Efavirenz enhances HIV-1 RT p66/p66 and p51/p51 homodimer interactions
HIV/AIDS Research - Expression system provides hydrophobic peptide from HIV-1 p24 protein
HIV/AIDS Research - Redox status of cells regulated through complex and tightly regulated mechanism
HIV/AIDS Vaccines - Reports describe recent advances in HIV/AIDS vaccines research
Head and Neck Cancer - Endostatin diminishes angiogenic activity in squamous cell carcinoma
Hematology - Adeno-associated virus-mediated gene transfer fuels erythropoietin production
Hematology - Overexpressed HOXB6 gene is implicated in acute myeloid leukemia
Hepatic Injury - Acute hepatic injury studied, tributylmethyl ammonium excretion clarified
Hepatitis B Therapy - Interferon triggers anti-inflammatory activity in chronic hepatitis B patients
Hepatology - Cytoprotective TNF-alpha-inducible proteins identified in mouse liver
Hepatology - Stress-activated MAPKs mediate rubratoxin B-induced hepatotoxicity
Herpes - Herpes B virus recombinant glycoproteins have high diagnostic potential
Hormones - Corticotropin-releasing hormone examined, role in protein kinase activity shown
Hormones - Hormone levels in relation to body composition studied, patterns revealed
Huntingtin - Huntingtin examined, basis of impaired nuclear export defined
Hypercholesterolemia - LDL cholesterol studied, low leves in individuals of African descent revealed
Immunocontraception - Chimeric synthetic peptide shows promise in immunocontraceptive vaccines
Immunology - Batracyclin derived muramyl dipeptides studied, biological activity reported
Immunology - Reports describe recent advances in immunology research
Immunomodulation - Aloe polysaccharides studied, role of size in immunomodulation identified
Infections - Cryptococcus pulmonary infection studied, antibody protection clarified
Infectious Disease - Researchers discover how body regulates most abundant type of white blood cell
Inflammation - Histamine H1 receptor antagonist studied, effect on cytokine production revealed
Inflammation - Parotid secretory anti-inflammatory peptides designed and validated
Insulin Resistance - IKK-beta inhibition holds promise as a treatment for insulin resistance
Ischemia/Reperfusion - IMD1-53 reperfusion augmented coronary perfusion flow and LV systolic pressure
Lactobacillus Reuteri - Lsp and MsrB analyzed, role in Lactobacillus reuteri demonstrated
Leukemia Therapy - Fibromodulin used as a novel tumor-associated antigen in leukemia
Lipoproteins - Murein lipoprotein studied, role in Salmonella systemic infection defined
Liver Cancer - Aberrant Pim-3 expression encourages hepatocellular carcinoma proliferation
Liver Cancer - Lower incidence of intrahepatic recurrences via resection than radiofrequency
Lung Cancer Tumorigenesis - Rare Met proto-oncogene juxtamembrane variations linked to tumorigenesis
Malaria Vaccines - New data illuminates research in malaria vaccines
Male Infertility - Mice with defective sperm offer clues to infertility in men
Matrix Metalloproteinase - MMP-9 gelatinase B examined, expression and activation in endometrium clarified
Melanogenesis - Glycyrrhizin induces melanogenesis by cAMP elevation in melanoma cells
Melanoma - Novel melanoma antigen FCRL/FREB is immunogenic in multiple melanoma patients
Melanoma - Targeting mutant B-Raf protein reduces melanoma development
Melanoma Oncogenesis - Mutations in the tumor suppressor INK4A linked to melanoma
Memory - Cortistatin investigated, modulation of memory evocation revealed
Meningococci - Region of bactericidal antibodies of Neisseria meningitides is identified
Mental Health - Neurotrophic factor analyzed, involvement in macrophage activation revealed
Micelles - Reverse micellar systems examined, protein back-extraction processes clarified
Microarray Analysis - Novel QRT-PCR-based exponential sample amplification method developed
Mitochondria - Endothelial cell mitochondria examined, respiratory uncoupling revealed
Mitofusins - Mitofusins studied, roles in mitochondrial fusion reactions defined
Molecular Biology - RNA project to create language for scientists worldwide
Multiple Myeloma - PML mediates IFN-alpha-induced myeloma apoptosis by regulating TRAIL induction
Mutagenesis - Hepatitis C type 1b E2-PePHD mutations are not linked to treatment response
Neuroblastoma - Human neuroblastoma cell growth inhibited by CAY10404
Neurodegenerative Disease - Three researchers receive 2005 awards for studies of neurodegenerative diseases
Neurology - Amylold beta peptide studied, effects of induced Ca2+ signals defined
Neurology - CaV 1.3 L-type calcium channels examined, association with Shank reported
Neurology - LPS-mediated activation of c-fos studied, nature of pathway clarified
Neurology - Microglia nitric oxide production studied, nature of dependence clarified
Neurology - New findings in the area of neurology detailed
Neuroscience - CREB phosphorylation analyzed, critical factors identified
Neuroscience - Caspase-3 causes brain capillary endothelial and cancer cells to self-destruct
Obesity Pathogenesis - Reports add new data to obesity pathogenesis research
Obesity and Diabetes - Data advance knowledge in obesity and diabetes research
Obstetrics - Mouse study suggests link between estrogen excess and thrombotic fetal loss
Olfaction - Vomeronasal receptor neurons studied, maturation clarified
Oncogenesis - Laser detection of cancer cells also may improve understanding of stem cells
Oncogenic Osteomalacia - Fibroblast growth factor 7 plays a role in mediating oncogenic osteomalacia
Oncology - DNA-PK inhibition is a viable strategy for enhancing ionizing radiation
Oncology - Dominant B cell epitope from NY-ESO-1 may be a potential biomarker
Oncology - Drugs that challenge Ero1-L alpha may beat hypoxia-generated tumor growth
Oncology - Gene expression profiles of papillary thyroid cancer are easily identified
Oncology - Oncolytic virus and radiotherapy join to treat squamous cell carcinoma
Oncology - Reports advance knowledge in oncology research
Oncology - Ron receptor signals influence mammary tumor development and metastasis
Oncology - STAT3 decoy erases tumor growth in xenograft models
Pancreatic Cancer - Increased expression of betaTRCP1 associated with chemoresistance
Parkinson Disease - Continuous L-DOPA delivery reverses dyskinesia in an animal model
Patents - DNA-focused company announces issuance of patent on gene delivery technologies
Peptide Elongation Factor - Lipopolysaccharide removal by a peptide-functionalized surface demonstrated
Peptide Elongation Factor - Peptide interactions with anionic lipid membranes simulated
Periodontitis - Periodontitis studied, role of proteinase-activated receptor-2 agonist revealed
Personnel - Biology-based company appoints CFO and VP research to management team
Personnel - Proteomics technology company announces management team reorganization
Pharmaceuticals - Cysteine and hydrogen peroxide reaction kinetics and mechanism clarified
Physiology - Cryptococcus neoformans mannoproteins studied, cellular role defined
Physiology - Stratum corneum studied, proteinase effects of glycolic acid revealed
Physiology - Studies advance knowledge in physiology research
Platelets - Rap1 activation in human platelets analyzed, nature of inhibition revealed
Product Licensing - Biotech company and Max Plack Society sign product license agreement
Protein Kinase - Protein kinase C isoforms studied, distinct roles in neurite outgrowth revealed
Proteomics - Angiogenin promotes cancer cell proliferation as well as angiogenesis
Proteomics - Angiopoietins are direct activators of endothelial cells and neutrophils
Proteomics - Bcl-2 protein analyzed, expression after ischemic preconditioning revealed
Proteomics - Fibroblast growth factor 2 upregulates p12 in endothelial cells
Proteomics - GFP-fragment reassembly studied, protein-protein interactions documented
Proteomics - Hela-type caldesmon delineates tumor endothelial cells
Proteomics - Nonsynonymous single nucleotide polymorphisms studied, cell cycle effects noted
Proteomics - PSD95-nNOS interface examined, role in stress-activated events clarified
Proteomics - Spectral magnitude effects on CD spectra-derived secondary structure determined
Proteomics - Studies describe new findings in proteomics research
Proteomics - Vasohibin controls gene expression in endothelial cells
Proteomics - Xenopus oocyte glutamate transporter examined, syntaxin regulation revealed
Pulmonary Medicine - Research in pulmonary medicine provides new insights
Receptor Studies - Study examined adenosine receptors in resveratrol preconditioning
Recombinant Proteins - Mutagenesis of hlyB improves secretory production of recombinant proteins
Schizophrenia - RGS4 polymorphisms linked to altered DLPFC morphometry
Skin Cancer - Alterations of mtDNA in malignant melanoma not induced by UV radiation
Smooth Muscle Cancer Diagnostics - Myoepithelial cell markers in salivary gland neoplasms identified
Squamous Cell Carcinogenesis - Expression of FHIT in squamous cell cancer and premalignant lesions of larynx
Stem Cell Research - Companies announce collaboration on diabetes-focused stem cell studies
Streptococcus Vaccines - Data advance knowledge in streptococcus vaccines research
Stroke - Atorvastatin restores brain function after cerebral infarction
T-Cell Receptors - T cell receptors can be generated by mutations in CDR1, CDR2 or CDR3
Thrombosis - Inflammatory bowel disease studied, role of hyperhomocysteinaemia clarified
Thyroid - Thyroid nodules examined, expression of cell cycle-associated genes revealed
Tissue Engineering - Hydrogel scaffold developed for cell adhesion and neural outgrowth
Tissue Engineering - Hydrogel scaffolds containing angiogenic cytokine direct cell migration
Tissue Engineering - RGD peptides/FBS regulate MSC attachment/spreading on hydroxyapatite
Titanium Dental Implants - Role of laminin-5 in peri-implant epithelium formation clarified
Transfusion - Heme-peptides will not trigger an adverse immune response in transfusion
Transplant Medicine - Chemoattractant protein studied, role in murine islet transplantation revealed
Transplant Medicine - Studies describe new findings in transplant medicine research
Tuberculosis - Mycobacterium tuberculosis proteasomal ATPase homologue characterized
Tuberculosis - CSF induced by 30-kDa secretory protein of Mycobacterium tuberculosis H37Rv
Tuberculosis - Researchers have characterized novel secreted antigens of M. tuberculosis
Type 1 Diabetes - Scientists investigate viral infection during Type 1 diabetes development
Type 2 Diabetes - -866G/A polymorphism of the UCP-2 gene linked with reduced diabetes risk
Uroguanylin - Uroguanylin analyzed, role in rats with experimental nephrotic syndrome defined
Uterine Leiomyoma - Altered laminin beta1 gene expression is associated with tumorigenesis
Vaccine Development - S. pneumoniae protein elicits antibodies that reduce colonization
Vaccine Development - Researchers examine protein dynamics at spindle poles
Vaccine Development - Telomerase vaccine study results in metastatic prostate cancer patients released
Vaccines Adjuvant - Researchers detail new studies and findings in the area of vaccines adjuvant
Virology - Banna virus outer coat protein VP9 studied, structure and function reported
Virology - Bovine Papillomavirus protein examined, critical structure identified
Virology - Hepatitis C virus protein mutations fuel antiviral resistance
Virology - New data illuminates research in virology
Virology - Newly identified protein may inhibit hepatitis virus
Virology - SARS-coronavirus examined, Orf7a accessory protein characterized
West Nile Virus - WNV-DIII envelope protein linked to binding to surface receptor of host cells
Zinc Deficiency - Molecular changes in hepatic lipid metabolism identified in rats
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