Proteomics Weekly
Susan Hasty, Publisher
Table of Contents . . . April 25th, 2005
Non-Subscriber - Summaries OnlyRelated Areas: Other Issues in Proteomics Weekly | Other Publications
Autoimmune Disease - Decay-accelerating factor (CD55) examined, nature of expression clarified
Clostridium Difficile - Clostridium difficile examined, surface protein immunology clarified
Depression - Proteolysis of SNARE proteins analyzed, effect on depression defined
Heat Shock Protein - Heat shock protein inducer examined, ischemic neuroprotective effect shown
Malaria - Plasmodium falciparum studied, overexpression of surface proteins revealed
Actin - Actin dynamics analyzed, tropornyosin-mediated cell movement clarified
Acute Promyelocytic Leukemia - Sumoylation site in PML/RARA deemed essential for leukemic transformation
Adipogenesis - Regulation of PPAR-gamma activity during adipogenesis reviewed
Adipose Tissue - Abundance of preadipocyte subtypes varies among fat depots
Adipose Tissue - Brown adipose tissue mitochondria show different morphological features
Adipose Tissue - Depot differences found in steroid receptor adipose tissue expression
Cancer Vaccines - Recent findings in cancer vaccines described
Adipose Tissue - Muscle-type carnitine palmitoyltransferase I characterized
Aging - Age-associated oxidative damage studied, role in lens gamma-cystathionase shown
Alcohol Use - Alcoholism reduces male heart's ability to synthesize protein
Allergy & Immunology - Asthmatics naturally deficient in antiviral immunity
Alzheimer Disease - A dietary omega-3 fatty acid could protect against Alzheimer, mouse study shows
Alzheimer Disease - Alzheimer amyloid beta precursor studied, alpha-secretase cleavage shown
Cancer Vaccines - Research in cancer vaccines provides new insights
Alzheimer Disease - Anthraquinones examined, effect on Alzheimer paired helical filaments revealed
Alzheimer Disease - Aph-1 analyzed, cell surface interactions revealed
Alzheimer Disease - Drug discovery company announces initiation of phase Ib of Alzheimer study
Alzheimer Disease - GM1-mediated Abeta accumulation on living cells visualized
Alzheimer Disease - Gamma-secretase studied, location and behavior clarified
Alzheimer Disease - Recent findings in Alzheimer disease provide new insights
Cardiology - Studies advance knowledge in cardiology research
Alzheimer Disease - Researchers identify gene that may increase risk of late-onset Alzheimer disease
Alzheimer Disease Therapy - Tacrine distribution in rat brain characterized
Amyloid Angiopathy - Amyloid-beta deposition studied, aspects in dementia with Lewy bodies clarified
Amyloid Peptides - Amyloid beta peptide examined, effect on mitochondria revealed
Anemia Risk Factors - CD59 glycation impairs complement control on erythrocytes in diabetes
Angiology - Platelet glycoprotein-von Willebrand factor complex studied, effects shown
Cardiology - Studies describe new findings in cardiology research
Angiology - Recent studies add new data to angiology research
Angiotensin - Angiotensin II analyzed, influence on homeobox expression revealed
Angiotensin - Angiotensin metabolism pathway suggested to be unrelated to ACE
Angiotensin - PI-PLC beta studied, role in angiotensin-mediated modulation demonstrated
Anorexia Nervosa - Fenfluramine accelerates weight loss from activity-based anorexia
Apoptosis - Akt inhibition studied, regulatory effects in lymphocytes revealed
Diabetes Pathogenesis - Studies advance knowledge in diabetes pathogenesis research
Apoptosis - Bovine leukemia virus involved in induction and inhibition of apoptosis
Apoptosis - Intracellular overproduction of apolipoprotein L6 induced apoptosis
Apoptosis - Peripheral-type benzodiazepine receptor ligands amplified neuronal apoptosis
Apoptosis - Resveratrol regulated PKC alpha and delta to inhibit growth and induce apoptosis
Apoptosis - Zinc studied, effects on gene expression in embryonic cells revealed
Apoptosis - c-Jun kinase studied, post-ischemic influence in hippocampal neurons revealed
Diabetes Pathogenesis - Studies describe new findings in diabetes pathogenesis research
Aquaporin - Aquaporin-5 analyzed, acute and chronic cAMP effects observed
Arthritis - Ulmus davidiana extract suppresses collagen-induced arthritis
Arthritis Pathogenesis - Plasminogen activator system needed for joint inflammation of arthritis
Astrocytes - Cytokine-stimulated astrocytes analyzed, nitric oxide synthase regulation shown
Atherosclerosis - Endothelial inflammation in insulin resistance reviewed
Atherosclerosis Therapy - Anti-atherosclerotic mechanisms of implitapide elucidated
HIV/AIDS Vaccines - Reports advance knowledge in HIV/AIDS vaccines research
Autoimmune Disease - Chronic idiopathic urticaria wheals studied, cells and cytokines clarified
Autoimmune Disease - Novel immunosuppressant analyzed, effects in autoimmune glomerulonephritis shown
Bacteriology - Antigen presentation and recognition in bacterial infections reviewed
Beta-Amyloid - Beta amyloid fibril examined, protective role of an alpha-crystallin revealed
Beta-Amyloid Peptides - Macrophage inflammatory protein analyzed, role in neuronal apoptosis revealed
Biomedical Engineering - Preadipocyte differentiation enhances insulin production
HIV/AIDS Vaccines - Researchers report details of new studies and findings in the area of HIV/AIDS vaccines
Biotechnology - Lipopolysaccharides removed from protein-lipopolysaccharide complexes
Bladder Cancer - Cylooxygenase-2 overexpression encourages tumor growth in murine bladders
Bone Cancer - Herceptin and taxol may be effective combination therapy for Ewing sarcoma
Bone Marrow - OPF hydrogels useful in guided bone regeneration
Brain Development - CNTF/LIF/gp130 receptor complex involved in developing ventral forebrain
Breast Cancer - Extracellular matrix protein collagen VI can modulate tumor behavior
Neurology - Recent findings in neurology provide new insights
Breast Cancer - Glucocorticoid receptor activation protects tumor cells via MAPK inhibition
Breast Cancer - PKC delta and MAPK mediate G(1) arrest induced by PMA in SKBR-3 breast cancer
Breast Cancer - Researchers publish new studies and findings in the area of breast cancer
Breast Cancer - Twist and Wnt genes are highly expressed in breast cancer
Breast Cancer Research - Copper and zinc induced apoptosis in breast cancer cells
Breast Cancer Vaccine - Structural consequences of increasing repeats in MUC1 tumor antigen reported
Neuroscience - Researchers describe findings in neuroscience studies
Business & Finance - Provider of DNA/RNA research tools secures additional financing
Cancer Cachexia - Effect of cancer cachexia on the activity of tripeptidyl-peptidase II measured
Cancer Cell Inhibitors - Novel inhibitors of human histone deacetylases discovered
Cancer Cell Morphogenesis - Tetraspanin CD82 attenuated cellular morphogenesis
Cancer Cell Survival - H-RAS and K-RAS associated with cell survival
Cancer Drugs - Hsp90 and Cdc37 nominated as possible cancer drugs
Neuroscience - Researchers detail new studies and findings in the area of neuroscience
Cancer Immunotherapy - Combinations of monoclonal antibodies limit tumorigenesis
Cancer Research - Spatially distinct binding of Cdc42 to key effector proteins studied
Cancer Risks - Fanconi anemia led to increased cancer risk
Cancer Risks - Reduction of E2F/DP activity might increase risk of cancer
Cancer Survival - Increase in S100A4 associated with decrease in cancer survival
Cancer Therapy - Findings describe new data in cancer therapy research
Obesity Surgery - Researchers publish new studies and findings in the area of obesity surgery
Cancer Therapy - Genetic testing could bolster radiotherapy's effectiveness against cancer
Cancer Therapy - Human MUC1 oncoprotein regulated p53-responsive gene transcription
Cancer Therapy - Novel mechanism of checkpoint abrogation conferred by Chk1 downregulation
Cancer Therapy - Silatecan DB-67 showed promise in treating cancer
Cancer Therapy - Transcription factor 3 contributed to curcumin's proapoptotic effect
Cancer Vaccine - General cancer vaccine that targets survivin developed
Oncology - Recent findings in oncology provide new insights
Cancer Vaccine - Mass spectrometry used to detect specific MHC class I peptide antigens
Cancer Vaccine - Monocyte-derived dendritic cells present malignant glioma tumor cell lysates
Cancer Vaccine - N-modified GM3 antigens synthesized as therapeutic cancer vaccines
Cancer Vaccines - New research in the area of cancer vaccines detailed
Oncology - Reports add new data to oncology research
Carcinogens - DNA damage and adduct formation in rat tissues after acrylamide administration
Cardiac Arrest - In anoxia, why can't humans be more like western painted turtles?
Cardiac Hypertrophy - Researchers detail new studies and findings in the area of cardiac hypertrophy
Cardiology - A1 adenosine receptor deletion limits myocardial tolerance of ischemia
Cardiology - Researchers provide details of new studies and findings in the area of cardiology
Cardiology - Sarcalumenin deficiency studied, impaired Ca2+ muscle stores revealed
Oncology - Researchers' findings advance oncology research
Cardiomyocytes - Intracellular S100A1 modulates cardiac Ca2+-turnover
Cardiomyocytes - PDGF beta receptor is involved in growth response of rat cardiomyocytes
Cardioprotection - Nonerythropoietic derivatives may be more effective for treating CV diseases
Cardiovascular Research - Apelin may have a key role as a paracrine cardiovascular regulator system
Virology - Researchers provide details of new studies and findings in the area of virology
Cardiovascular Research - Combined growth factors may be superior angiogenesis stimulants
Cardiovascular Research - Study explored role of CRP as a modulator of inducible nitric oxide synthase
Catalase - Smooth muscle nitric oxide synthase studied, catalase potentiation revealed
Cataracts - Gamma D-crystallin mutation studied, effect on cataract formation clarified
Cell Biology - Actual length of terminal telomere repeats recorded by new method
Cell Biology - Cdc42 regulates shear-induced nucleus movement in fibroblasts
Cell Biology - Chloroquine may have a role in iNOS expression, NO production
Cell Biology - Pair of cancer genes found to drive both cell migration and division
Cell Biology - Rictor-mTOR complex may be drug target
Cell Biology - Structure conservation among cytochromes P450 compared
Cell Development - Blastocyst attachment on fibronectin studied, integrin mediation revealed
Cerebro-Ventricular Grafting - Alzheimer pathology modulated by hybridoma cells expressing A-beta antibodies
Cervical Cancer - Killer cell immunoglobulin-like receptor population affects disease risk
Cervical Cancer - New findings in the area of cervical cancer detailed
Chondrosarcoma - Tumor cell apoptosis induced by novel PPARgamma agonist characterized
Chronic Liver Disease - Aryl hydrocarbon receptor makes liver cells vulnerable to apoptosis
Chronic Obstructive Pulmonary Disease - Key to treating killer disease may be uncovered by U.K. team
Coagulation - Initiator cells do not regulate thrombus growth rate
Collaborations - Medical products and diagnostics co. to develop neurodegenerative disease test
Collaborations - Research collaboration with International AIDS Vaccine Initiative announced
Colon Cancer - DKK-1 gene expression in human colon tumors seen to decrease
Colon Cancer - Galectin-4 bound to sulfated glycosphingolipids and carcinoembryonic antigen
Colon Cancer - H-RAS V 12 and K-RAS D13 regulated radiation-induced signaling pathway function
Colorectal Cancer - Myricetin inhibited enzyme activity in colorectal carcinoma cells
Complementary & Alternative Medicine - No ECG parameter was an independent predictor of plasma ANP concentration
Coronary Artery Bypass - Trial of drug for preventing coronary artery bypass graft failure initiated
Corticotropin-Releasing Factor - CRF receptor variant studied, binding and modulation described
Cystatin - Brugia malayi cystatin studied, difference from C. elegans shown
Cystatin - Cystatin C deficiency studied, effects in apolipoprotein E-null mice revealed
Cytomegalovirus - Cytomegalovirus cell-to-cell spread studied, role of assembly protein defined
DNA Binding - Combinatorial identification of the covalent DNA-binding polyamide tallimustine
DNA Research - Charge transfer bands' effect on the photo-induced DNA cleavage activity studied
DNA Research - Nucleotide sequence variation found often in mitochondrial DNA of tumor cells
DNA Tumor Viruses - Hope placed in DNA tumor viruses to help understand cancer cell programming
Dermatology - Antisense oligodeoxynucleotide G3139 activates melanoma cell apoptosis
Diabetes Education - Life sciences company releases informational brochure on obesity and diabetes
Diabetes Genomics and Genetics - Link between E23K Kir6.2 polymorphism and type 2 diabetes reviewed
Diabetes Pathogenesis - Aberrant regulation of IL-12 receptor found in type 1 diabetes
Diabetes Pathogenesis - CaV 2.3 calcium channels control second-phase insulin release
Diabetes Pathogenesis - Glucose-dependent insulinotropic polypeptide regulates beta-cell fate
Diabetes Pathogenesis - Researchers' data advance diabetes pathogenesis research
Diabetes Pathogenesis - Transcriptional basis for corticosteroid insulin resistance studied
Diabetes Therapy - Bosentan decreases glucose levels without effects on insulin secretion
Diabetes Therapy - Flavonoid antioxidant prevents beta-cell damage in rat pancreas
Diabetes Therapy - Recent findings in diabetes therapy described
Diabetes Therapy - Role of glucagon-like peptide 1 in treatment of diabetes reviewed
Diabetes Therapy - Vascular reactivity different using gliclazide and glibenclamide
Diabetic Nephropathy - High sympathetic activity, low adiponectin predict poor outcomes
Diabetic Nephropathy - Measuring products of non-enzymatic glycation of proteins is important
Diabetic Nephropathy - Studies advance knowledge in diabetic nephropathy research
Diabetic Nephropathy - VEGF inhibition has little effect on the kidneys of type 2 diabetes models
Diabetic Neuropathy - Findings advance knowledge in diabetic neuropathy research
Diabetic Retinopathy - Advanced glycation end products alter angiogenic phenotypes in diabetic eyes
Diagnostics - SELDI-TOF mass spectrometry profiles cancer risk in patients with hepatitis C
Diet & Nutrition - Mechanism underlying soy phytoestrogen's cardioprotective effects elucidated
Diet & Nutrition - Protein restriction may slow aging
Disease Associations - H. pylori infection led to intestinal atrophy, metaplasia and gastric cancer
Disease Associations - ARPKD duct cell sodium absorption studied, abnormal regulation revealed
Disease Associations - Alexander disease studied, age-related presence of mutations demonstrated
Disease Associations - Gq/11 family g proteins studied, link to hypoplasia and dwarfism revealed
Disease Associations - Hepatic stellate cells examined, adipogenic transcriptional regulation defined
Disease Associations - Homocystinuria analyzed, homocysteine effects on cbEGF domain clarified
Disease Associations - Tamm-Horsfall protein investigated, renal effects chronicled
Disease Associations - Toll-like receptor 2 agonist analyzed, serum location and LPS syngery revealed
Disease Associations - Xeroderma pigmentosum skin reconstructed to study genetic hyperphotosensitivity
Disease Associations - Yersinia protein tyrosine phosphatase studied, role in virulence clarified
Drug Delivery - Cell-specific systems improve drug and gene delivery
Drug Delivery - Dimeric RGD peptide-paclitaxel conjugate abates tumor proliferation
Drug Delivery - Novel system provides sustained delivery of protein therapeutics
Drug Delivery - Report: Device technology shaping delivery of new therapeutics
Drug Development - Assay kit for kinase and phosphatase development introduced
Drug Development - Daiichi enters funded-research agreement
Drug Metabolism - Metabolism of alfentanil by CYP3A enzymes characterized
Drug Metabolism - Montelukast is a selective CYP2C8 inhibitor
Drug Resistance - Flavonoid BCRP inhibitors don't affect topotecan pharmacokinetics in rat model
Drug Resistance - Intercellular transfer of P-glycoprotein mediated multidrug resistance in tumors
Drug Therapy - Nonpeptide CGRP receptor antagonist studied, species selectivity revealed
Dysautonomia - Yeast discovery offers better understanding, future cure of devastating disease
E. Coli Vaccine - Pellet formulation of F4 fimbriae for E. coli vaccine developed
Encephalomyelitis Vaccine - Targeting Fn14 signaling protects against autoimmune encephalomyelitis
Endocrinology - Fibroblast growth factor receptor is a target for thyroid cancer therapy
Endocrinology - Leptin fragments investigated, hypothalamic Fos immunoreactivity clarified
Endocrinology - PR expression differs between sexes in mouse lower urinary tract
Endocrinology - Recent studies add new data to endocrinology research
Endocrinology - Steroid receptor expression by endometrial endothelial cells determined
Endothelium - Sedentary life of lab mice does not lower endothelial function
Enzymology - Matrix metalloprotease-1 uses protease-activated receptor to trigger metastasis
Esophageal Cancer - Defective mismatch-repair linked to Barrett esophagus-associated adenocarcinoma
Evolutionary Biology - Human chromosomes 2, 4 include gene deserts, signs of chimp chromosome merger
Finance - Food and animal safety company reports 48th consecutive profitable quarter
Finance - RNAi-focused company reports Q4 net loss of $5.8 million
Folate - Folate reabsorption studied, role of folate binding protein 1 revealed
Follicular Thyroid Cancer - Expression profiling revealed transcription signature in thyroid carcinomas
Fragile X Syndrome - Fragile X syndrome studied, nature of mRNA regulation in brain clarified
Gap Junctions - Novel GAP-like protein examined, influence on connexin revealed
Gastric Cancer - Lysophospholipids transactivate HER2/neu (ErbB-2) in gastric cancer cells
Gastroenterology - Fur- and iron-regulated H. pylori genes identified
Gene Research - DNA probes dissect the genetics of B-cell chronic lymphocytic leukemia
Gene Research - Top companies in gene expression analysis market identified in survey report
Genetic Engineering - Human genes corrected
Genetics & Genomics - Nucleosome dynamics modulated by histones
Genetics & Genomics - Researchers trace evolution of a single gene controlling armor styles in fish
Ghrelin - Ghrelin examined, chondrocyte synthesis and secretion documented
Ghrelin - Ghrelin studied, involvement in cell proliferation clarified
Glucocorticoid Receptors - Glucocorticoid receptor studied, differential effects on dynein revealed
Glucocorticoid Receptors - Glucocorticoid repressed genes examined, differential regulation clarified
Gonadotropins - Hormone release and secretion studied, effects of polypeptide YY3-36 clarified
Gynecology - New findings in the area of gynecology detailed
Gynecology - Specific gene sets influence the direction of leiomyoma growth
HIV/AIDS Metabolism - Reducing HIV RNA improves muscle amino acid metabolism
HIV/AIDS Pathogenesis - Natural variability of HIV-1 Tat protein explored
HIV/AIDS Therapy - Multidrug resistance-associated proteins limit saquinavir brain uptake
HIV/AIDS Vaccine - Clustered epitopes of Gag-Pol fusion protein enhance immunity against HIV
HIV/AIDS Vaccine - Dendritic cell vaccine confers partial protection against HIV-1
HIV/AIDS Vaccine - T-cell engineering by T-cell receptor with HIV-1 gp120 specificity reported
HIV/AIDS Vaccines - New data illuminates research in HIV/AIDS vaccines
HIV/AIDS Vaccines - Stanford study finds HIV drug resistance assay superior to Virco's Antivirogram
HTLV-1 - HTLV-1 HBZ suppresses AP-1 activity by impairing DNA-binding/c-Jun stability
Head and Neck Cancer - Cdc42/Rac1 involved in controlling telomerase activity in nasopharyngeal cancer
Head and Neck Cancer - Small interfering RNA disrupts DNA methyltransferase and stops cancer growth
Health Promotion - Diagnostics company funds cervical cancer awareness campaign
Helicobacter Pylori - Salivary molecules studied, role in cell and Helicobacter adhesion clarified
Hepatocellular Carcinoma - The p19ARF peptide may have use in treatment
Hepatology - Cytokine cross-talk reconstitutes liver growth following liver injury
Hepatology - Effects of muscle unloading on liver metabolism characterized in rats
Hippocampus - Hippocampal granule cells studied, calbindin content and firing pattern shown
Hormone Replacement Therapy - Findings in hormone replacement therapy provide new insights
Hormones - Hormone-sensitive lipase analyzed, 'regulatory module' characterized
Hormones - Protein kinase studied, role in ovarian oocyte maturation clarified
Huntington Disease - Researchers improve brain disease symptoms in mice
Hypoxia - Role of CBP in regulating HIF-1-mediated activation of transcription defined
Idiopathic Pulmonary Fibrosis - Volunteers needed for university study of idiopathic pulmonary fibrosis
Immunology - Inactivation of proximal TCR signaling impairs T-cell-mediated tumor lysis
Immunology - Long-term spaceflight affects immunoglobulin heavy chains
Immunology - Mouse model quantitates endothelial activation in vivo
Immunology - Novel variant of acyl-CoA synthetase isoform 6 identified
Immunology - Pro-IL-16 regulation characterized in activated mouse CD4 cells
Immunology - Regulation of S100A8 by glucocorticoids characterized
Immunology - Reports describe recent advances in immunology research
Immunology - Vascular endothelial cells examined, impaired immunopresentation described
Infections - Lactobacillus fermentum BspA studied, protein characterized
Inflammation - Platelet P-selectin studied, requirement in allergic inflammation clarified
Inflammation - Secretoneurin analyzed, effects on killer cells and cytokines revealed
Information Technology - Life sciences and high technology company releases brochure on ion channels
Insulin Resistance - Role of brown adipose cell in insulin resistance reviewed
Insulin Secretion - Inhibition of phospholipase A2 impairs glucose tolerance
Insulin Secretion - PKC lambda regulates insulin secretion by gene expression modulation
Ischemia - Hippocampus analyzed, post-ischemic protein disulfide changes revealed
Ischemia - Study investigated mechanisms regulating AMPK phosphorylation in ischemic hearts
Keratinocytes - Keratinocyte differentiation studied, role of enzyme activation clarified
Leprosy Risk Factors - Genetics of immunity in leprosy reviewed
Leptin Studies - Recent findings in leptin studies described
Leukemia - Uncoupling protein 2 and reactive oxygen species characterized
Leukemia Vaccine - Multidrug resistance of leukemia cells decreases tumorigenicity
Leukemia Vaccine - Protein kinase blockade stops change of myeloid blasts into dendritic cells
Liver Cancer - Alpha-1,3-fucosyltransferase-VII stimulated growth of hepatocarcinoma
Lung Cancer - Major vault protein does not play a role in chemoresistance or drug localization
Lung Cancer - Oral supplementation of piperine altered phase II enzymes and reduced DNA damage
Lung Cancer - Overexpressed soluble TRAIL initiates the destruction of lung adenocarcinoma
Lyme Disease - Lyme disease spirochete protein examined, critical binding structure identified
Lymphoma - APl2-MALT1 fusion protein implicated in t(11;18)(Q21;q21) MALT lymphoma
Lymphoma Vaccine - Rapid expression of vaccine proteins for B-cell lymphoma developed
Lysozyme - Lysozyme studied, novel racemization process demonstrated
Machado-Joseph Disease - The tail of the gene tells the tale of brain disease
Malaria - Plasmodium vivax antigen binding domain studied, critical residues mapped
Malaria Vaccines - Researchers report details of new studies and findings in the area of malaria vaccines
Melanocortin Receptor - Melanocortin receptor activation studied, effect on heme oxygenase revealed
Melanoma - Hepatocyte growth factor induced fibronectin matrix synthesis in melanoma cells
Melanoma - Peptide recognized by autologous cytolytic T lymphocytes on melanoma cells
Melanoma - Rac-WAVE2 involved in invasive and metastatic phenotypes of murine melanoma
Melanoma Vaccine - Invasive melanoma cells induce metalloproteinase synthesis in fibroblasts
Melanoma Vaccines - Reports advance knowledge in melanoma vaccines research
Meningococcal Disease - PorA protein relatively stable during meningococcal disease epidemic
Metabolic Syndrome - Nutrient-dependent responses to visceral and subcutaneous fat depots studied
Metastasis - New technique finds molecules necessary for cancer spread
Molecular Biology - Binding specificity of RNA nucleotides studied
Molecular Biology - New structural insights into RNA interference
Multiple Sclerosis - EBV inflames multiple sclerosis
Mycology - Cycle time effect on fungal morphology during carbon addition studied
Myelodysplastic Syndrome - Findings describe new data in myelodysplastic syndrome research
Nanotechnology - National Science Foundation awards grant to nanotechnology company
Natural Products - The flavonoid nobiletin reduces the metastatic potential of colon cancer
Neural Development - Thrombospondins analyzed, role in CNS synaptogenesis defined
Neurology - Findings in neurology provide new insights
Neurology - Hameodomain transcription factor studied, transcriptional corepressor described
Neurology - Hippocampal pyramidal neurons analyzed, excitability potentiation revealed
Neurology - Senataxin mutations causing Quebec cluster of atria with neuropathy studied
Neuropeptides - Neuropeptide receptor studied, desensitization and internalization clarified
Neuroscience - AMPH lowers neuropeptide Y immunoreactivity in rat hypothalamic paraventriculum
Neuroscience - Epigenetic stimulation provides long-term expansion of neural progenitor cells
Neuroscience - Fly studies raise possibility of new treatments for inherited brain disorders
Neuroscience - Mayven involved in oligodendrocyte process elongation
Neuroscience - Protein sigma1s contributes to reovirus pathogenesis and virulence
Neuroscience - Recent findings illuminate research in neuroscience
Neuroscience - Role of S1P as autocrine/paracrine physiologic messenger in cerebellum supported
Neuroscience - Subcellular localization of APC protein determined in developing neurons
Neurotransmitters - Pituitary adenylate cyclase studied, role in active avoidance clarified
Neurotrophic factors - Signaling pathways and neurotrophic factor studied, inhibition revealed
Nutrition - Intestinal CYP3A4 inhibition at different times by grapefruit components shown
Obesity Complications - Kidneys promote clearance of growth hormone in obese patients
Obesity Pathogenesis - Adrenomedullin and receptor components expressed in rat adipose tissues
Obesity Pathogenesis - Leptin-like effects of MTII are augmented in MSG-obese rats
Obesity Pathogenesis - Nucleus accumbens neurons encode palatability and appetitive behaviors
Obesity Pathogenesis - Recent findings in obesity pathogenesis described
Obesity Pathogenesis - Transcriptional regulators and cofactors of PPAR-gamma reported
Obesity Surgery - Researchers detail new studies and findings in the area of obesity surgery
Obesity Therapy - "Second messenger" NAADP shows fast, dose-related impact on satiety cycle
Obesity Therapy - New data illuminates research in obesity therapy
Obesity and Diabetes - Glucose-dependent insulinotropic polypeptide is potential medication
Obesity and Diabetes - Metabolic consequences of physical inactivity reviewed
Oncology - Black bean tannins shut down angiogenic protein production in cancer cells
Oncology - COX-2 inhibition restores tumor suppressor activity in prostate cancer cells
Oncology - Data advance knowledge in oncology research
Oncology - Decoy receptor 3 enhances monocyte adhesion to endothelial cells
Oncology - Effects of p53 activation on healthy and tumor cells clarified
Oncology - Hepatitis C infection spurs liver cancer growth by blocking apoptosis
Oncology - Neuropeptide Y supports the growth and vascularization of neuroendocrine tumors
Oncology - Suppressed 6A8 alpha-mannosidase gene expression shortens cancer cell telomeres
Ophthalmology - Murine retinas require Bcl-2 expression for proper vascular development
Osteoclasts - Osteoclasts studied, role of protein kinase B clarified
Osteoporosis - Increased fatty acid production with age may be a bone-loss mechanism
Paramyxovirus - Paramyxovirus budding analyzed, critical role of late-domain sequence revealed
Patents - Company gets patent for its selective chemotherapy treatment, NQO2
Patents - Company wins patents for AequoScreen, high-throughput screening method
Patents - Pharma company issued European patent for gastrointestinal technology
Peptides - CART peptide fragment 55-102 may excite neurons in intermediolateral cell column
Peripheral Arterial Disease - Article reviews evidence for use of ACE inhibitors in patients with PAD
Personnel - Biopharma company announces board of directors nominations
Personnel - Harvard professor James Winkelman named SAB chair by DNA diagnostics company
Phosphatase - Oncoprotein 1-2(PP2A)/SET examined, negative regulatory activity documented
Photosynthesis - Proteoliposomes examined, role in photosynthesis clarified
Physiology - L-alpha-amino acid receptor GPRC6A studied, deorphanization described
Physiology - MARK inhibitors studied, inhibition of RIP2/RICK/CARDIAK activity revealed
Physiology - Nephrotic plasma examined, alterations in podocytes described
Physiology - Supraspinatus tendon overuse alters inflammation and angiogenesis markers
Prions - Prion protein examined, serotonergic receptor modulations revealed
Prions - Recent findings in prions described
Product Licensing - Protein design company expands license agreement with Genencor
Prostate Cancer - Composition and histone substrates of polycomb repressive complexes changed
Prostate Cancer - Magmas expression linked to neoplastic human prostate
Protein Expression - Proximal small intestinal CYP3A or P-glycoprotein expression same in men, women
Protein Kinase - Protein kinase C signaling examined, role as a survival pathway revealed
Proteomics - Adapter protein Tks5/Fish needed for podosome formation and cancer cell invasion
Proteomics - Chimeric proteins combine EngD PT region, HLD of cellulose binding protein A
Proteomics - Hepatitis C virus core protein mediates cellular response to TRAIL
Proteomics - Interferon-alpha induces protein production in CD4+ T cells
Proteomics - LDL contains a number of apolipoproteins, many in different isoforms
Proteomics - Plasma fibronectin guides angiostatic peptides to angiogenic vessels
Proteomics - Protein Brn-1 studied, functional replacement in Schwann cells observed
Proteomics - Protein-DNA interactions in T4 dNTP synthetase complex studied
Proteomics - Researchers provide details of new studies and findings in the area of proteomics
Proteomics - Results contrast with the current perception of IL-6 receptor activation
Proteomics - Thrombin uses alternate control mechanisms to regulate angiogenesis
Pseudomonas Aeruginosa - Alkaline phosphatase inhibitor studied, critical conformation revealed
Psoriasis - Hornerin analyzed, effects in psoriasis clarified
Pulmonary Medicine - Mitochondrial DNA damage triggers apoptosis in lung endothelial cells
Purinoceptor - ATP-stimulated ANP release through P1 receptor subtype
Receptor Studies - Urokinase receptor binding regulates alpha5beta 1 integrin function
Receptors - Adenine receptors examined, expression and characterization reported
Receptors - C5a receptor studied, site-specific disulfide capture of peptides achieved
Renal Disease - Angiotensin II expands VEGF production in response to renal injury
Renal Failure - Blood pressure control is very effective in retarding renal disease progression
Renal Failure - Transforming growth factor may influence vascularity in ischemic kidneys
Reproductive Biology - Reports advance knowledge in reproductive biology research
Reproductive Biology - Research on multiple vs. single births may offer new approaches for infertility
Response Regulation - Response regulators studied, signal-dependent promoter binding described
Retinopathy - Ectopic norrin restores normal retinal angiogenesis in Norrie disease models
Retroviral Research - Multiple SIV Env domains determine replication efficiency
Rett Syndrome - Effects of MECP2 mutations on gene expression profiles clarified
Rheumatoid Arthritis - Possible new phase identified for RA treatment
Rotator Cuff Disease - Molecular pathophysiology of subacromial bursitis elucidated
SARS - Research add new data to SARS body of knowledge
SARS Virus - Thermodynamics and kinetics of SARS virus glycoprotein folding investigated
Saccharomyces Genomics and Genetics - Characteristics of Saccharomyces expressing GAL promoter proteins listed
Salmonella Vaccine - Oral DNA vaccine developed using stabilized eukaryotic expression plasmids
Salmonella Vaccines - Findings in salmonella vaccines provide new insights
Sepsis - Hepatic CYP-mediated drug metabolism suppressed in rat model
Skin Cancer - Increased apoptosis led to decreased skin cancer in UV-irradiated CD1d-/- mice
Skin Cancer - Protein kinase C epsilon signaled ultraviolet light-induced skin cancer
Smooth Muscle - Corticotropin-releasing factor receptor studied, regulation clarified
Smooth Muscle - Ryanodine receptors play key role in gastric ICC pacemaker activity
Smooth Muscle - Staurosporine studied, inhibition of K+ coronary muscle cell current shown
Spermatozoa - Spermatozoa examined, occurrence of progesterone receptors clarified
Streptococcus - Oral streptococcal antigen adhesins studied, binding specificities shown
Synaptic Activation - Presynaptic mitogen-activated kinase activation studied, novel path revealed
Syndecan - Syndecan analyzed, invasion regulatory domain identified
Systemic Lupus Erythematosus - Study explores lupus and the role of Epstein-Barr virus
Toxicity - Aluminum effects examined, modification of enzyme activities described
Toxoplasmosis - Toxoplasma gondii virulence studied, synergistic protein role shown
Transplant Medicine - Adenovirus E3 protein protects transplanted cells from the immune system
Tuberculosis - Tuberculosis DNA discovered using patented transrenal DNA testing technology
Tumor Suppression - Role of PP2A as tumor suppressor inspected
Vaccine Adjuvant - Thymosin alpha 1-cBLyS fusion protein developed
Vaccine Development - Proteins modified by bacterial lipids used for protein engineering
Vaccines - Membrane-anchored microglobtilin studied, MHC stabilization observed
Vaccines - Prostaglandin E2 enhances intestinal adenoma growth
Vaccinia Virus - Wiskott-Aldrich syndrome protein needed for vaccinia virus pathogenesis
Vaccinia Virus Vaccine - Role of viral factor E3L in vaccinia virus infection of HeLa cells studied
Vascular Smooth Muscle - Vascular triacylglycerol accumulation studied, pathways defined
Vector Development - Transfection regimens shape Stat3 activity
Vector Development - Vector optimization sends oligonucleotides to cells with scavenger receptors
Virology - Findings advance knowledge in virology research
Virology - The effects of hepatitis C alternate reading frame and core protein overlap
Virology - Vesicular stomatitis virus pseudotypes help analyze early hepatitis C infection
Virology Vaccine - Vaccinia kinase features aid elucidation of virion morphogenesis mechanism
Xylanase - Cell wall protein used as fusion partner for expression of xylanase A
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