E. Coli Vaccine

Pellet formulation of F4 fimbriae for E. coli vaccine developed

Published in Proteomics Weekly, April 25th, 2005

Researchers have developed an enteric-coated pellet formulation of F4 fimbriae for oral vaccination of suckling piglets against enterotoxigenic Escherichia coli infections.

"A multi-particulate formulation of F4 fimbriae was developed for oral vaccination of suckling piglets against enterotoxigenic Escherichia coli infections. A feasibility test showed that incorporation of F4 fimbriae in a disintegrating pellet formulation consisting of 87.5% Pharmatose 200 M, 2.5% Avicel CL 611 and 10% Explotab by extrusion/spheronization and subsequent fluid bed drying resulted in the maintenance of 69±12% of the biological activity. But subsequent coating...

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Source: Proteomics Weekly (2005-04-25)

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