Insulin Secretion
Inhibition of phospholipase A2 impairs glucose tolerance
Published in Proteomics Weekly, April 25th, 2005
According to published research from the United States, "Islet Ca2+-independent phospholipase A2 (iPLA2 ) is postulated to mediate insulin secretion by releasing arachidonic acid in response to insulin secretagogues. However, the significance of iPLA2 signaling in insulin secretion in vivo remains unexplored. Here we investigated the physiological role of iPLA2 in beta-cell lines, isolated islets, and mice. We showed that small interfering RNA-specific silencing of...
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Source: Proteomics Weekly (2005-04-25)
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