Saccharomyces Genomics and Genetics

Characteristics of Saccharomyces expressing GAL promoter proteins listed

Published in Proteomics Weekly, April 25th, 2005

Researchers report the characteristics of Saccharomyces cerevisiae gal1 Delta and gal1 Delta hxk2 Delta mutants expressing recombinant proteins from the GAL promoter in a recent issue of Biotechnology and Bioengineering.

"Galactose can be used not only as an inducer of the GAL promoters, but also as a carbon source by Saccharomyces cerevisiae, which makes recombinant fermentation processes that use GAL promoters complicated and expensive. To overcome this problem during the cultivation of the recombinant strain expressing human serum albumin (HSA) from the GAL 10 promoter, a gal 1Delta mutant strain was constructed and its induction kinetics...

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Source: Proteomics Weekly (2005-04-25)

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