Proteomics Weekly

Gastroenterology - STI571 inhibited interaction between c-KIT and heat shock protein 90

Gastroenterology - Zona pellucida proteinase activity studied, embryonic differences noted

Gene Research - Valproic acid enhances gene transfer methods

Gene Silencing - Antisense thioredoxin may stop tumor angiogenesis by altering HIF-1

Gene Silencing - STAT3 knockdown shutters breast tumor formation in murine models

Gene Transfer - New data illuminates research in gene transfer

Genetics & Genomics - Cellular genes linked to radiation sensitivity identified

Genetics & Genomics - Research shows microbial DNA can diagnose vitality of any type of environment

Genetics & Genomics - Study describes the structure and expression of the mammalian HRC gene

Gestational Diabetes Mellitus - Inflammatory marker levels may indicate diabetes, IR in women with GDM history

Glucocorticoid Receptor - Stress analyzed, effects on specific brain protein levels revealed

Glutamate Receptor - Metabotropic glutamate receptor phospholipase C pathway studied

HIV-2 Pathogenesis - Functional domains within HIV-2 envelope required to enhance virus production

HIV/AIDS Drug Development - Molecular modeling reveals new HIV-1 IN binding site for nucleotide inhibitor

HIV/AIDS Pathogenesis - 42k and 55k isoforms of Cdk9 differentially regulated

HIV/AIDS Pathogenesis - Cooperative effects in phospholipid monolayers induced from HIV-1 capsid peptide

HIV/AIDS Pathogenesis - Reports advance knowledge in HIV/AIDS pathogenesis research

HIV/AIDS Vaccine - Single-stranded docking site enhances strand exchange by HIV

HIV/AIDS Vaccines - Findings describe new data in HIV/AIDS vaccines research

Heat Shock Protein - Heat shock protein 70 examined, role in clonogenicity of leukemic cells revealed

Hematology - Researchers provide details of new studies and findings in the area of hematology

Hepatitis C Therapy - The efficacy of BILN-2061 falters against hepatitis C genotypes 2 and 3

Hereditary Angioedema - Biotherapy company announces clinical study of hereditary angioedema therapy

Herpesvirus - Glycoprotein C-negative syncytial HSV mutants are pathogenic

Hormones - Glucagon-like peptide analyzed, properties and pharmacokinetics reported

Hormones - Gonadotropin releasing hormone analogues studied, peptide release clarified

Hormones - Thyroid-hormone examined, effects on putative biochemical pathways revealed

Human T-cell Leukemia Virus - Susceptibility to leukemia virus envelope-mediated fusion investigated

Hydrophobicity - Glycophorin dimerization motif analyzed, role of hydrophobic matching clarified

Hyperandrogenemia - VPA induces a PCOS-like genomic phenotype

Hypertension - Data showed differential activation of PKC in hypertensive rat hearts

Hypertension - Protein may have pathophysiological role in hypertension and oxidative stress

Imaging - Two-photon imaging gives real-time video of cells in living tissue

Immunology - Findings in immunology provide new insights

Immunology - Scientists reveal how disease bacterium survives inside immune system cell

Inflammation - TNF-alpha affects adipokine expression by adipocytes in culture

Inhibitors - Histone deacetylase inhibitors affected DNA methylation

Insulin - Ghrelin activates nitric oxide synthase in pancreatic islet cells

Insulin - Leptin secretion and protein kinase A activity examined

Insulin Resistance - Protein kinase C plays role in insulin resistance

Insulin Resistance - Reports add new data to insulin resistance research

Ischemia - Selenium affects tolerance to ischemia-reperfusion

Kidney Cancer - Human kidney injury molecule-1 identified as tissue and urinary tumor marker

Leptin Studies - Feedback inhibition of leptin receptor/Jak2 signaling investigated

Leptin Studies - Leptin receptor action and mechanisms of leptin resistance reviewed

Leptin Studies - Melatonin enhances leptin expression by adipocytes in insulin presence

Leptin Studies - Researchers' data advance leptin studies research

Leukemia - AML1-ETO fusion protein upregulated TRKA mRNA expression

Leukemia - Recurrent abnormality in chronic and acute leukemia fused PCM1 to JAK2

Leukodystrophy - Myelin formation examined, delay in arylsulphatase A-deficient mice shown

Lipid Bilayers - Amphiphilic copolymers studied, ability to disturb lipid bilayers clarified

Lipid Research - Apolipoprotein A-I deletions corrupt lipid metabolism in study models

Lipid Studies - Protein could be used as a marker for acute lung injury

Lipoproteins - Atherosclerotic plaques' nature of cholesterol mobilization clarified

Lipoproteins - Low-density lipoprotein analyzed, nature of thermal stability defined

Liver Cancer - Serological markers of liver cancer determined

Liver Cirrhosis - Hepatitis B virus pre-S2 mutant fosters hepatic hyperplasia

Macular Degeneration - Variation in immune response gene causes eye disease when triggered

Malaria - Recent findings in malaria provide new insights

Matrix Metalloproteinase - Triterpenoid studied, effect on matrix metalloproteinase expression shown

Medical Devices - ClinProt Micro solution for clinical proteomics launched at meeting

Metabolic Syndrome - Farnesoid X receptor may play regulatory role in metabolic syndrome

Metalloproteinase - Disintegrin-like metalloproteinases studied, effect of inhibitors clarified

Metastatic Colorectal Cancer - Pharma companies initiate phase 3 of PACCE study

Mitochondria - B cell mitochondria studied, associations of Bim BH3-only protein clarified

Multiple Sclerosis - Multiple sclerosis studied, specific intrathecal immunoglobulin G not detected

Mycobacteria - Polyketide synthases generate complex lipids in mycobacteria

Mycobacterium Tuberculosis - Dual role determined for N-terminal region of Mycobacterium tuberculosis

Myofibrillar Proteins - Myofibrillar proteins studied, detection technique described

Natural Products - Gac fruit extract diminishes tumor growth and neovascularization

Nervous System - Myenteric AH neurons examined, kinase isoform-specific translocation revealed

Neural Stem Cell Research - Tumor cells attract endogenous precursor cells whose presence is antitumorigenic

Neuroblastoma - Gene profiling of high-risk neuroblastoma conducted

Neurodegeneration - Matrix metalloproteinase variants are not linked to Alzheimer disease

Neurology - Reports describe recent advances in neurology research

Neurons - Synaptosomal associated protein analyzed, neuronal immunoreactivity shown

Neuropathy - Swiss cheese/neuropathy target esterase disruption analyzed, effects clarified

Neuropeptides - Fatty acid synthase inhibitor studied, effects on ghrelin secretion revealed

Neuropeptides - Neuropeptide Y and galanin analyzed, varying anxiolytic-like actions revealed

Neuroscience - Brn-3a deficiency analyzed, effect on primary ganglion nociceptors revealed

Neuroscience - Interleukin-10 gene polymorphisms are involved in Alzheimer disease etiology

Neuroscience - Intermedin has potent actions within the central nervous system

Neuroscience - Melanocortin receptor antagonist examined, anxiolytic-like effect defined

Neuroscience - Recent findings in neuroscience provide new insights

Neurotensin - Neurotensin studied, cellular uptake of a radiolabelled analogue explored

Obesity - Metabolic comorbidities enabled by adipose tissue cytokine gene expression

Obesity Genomics and Genetics - Findings in obesity genomics and genetics provide new insights

Obesity Genomics and Genetics - Microarray gene analysis identifies candidate gene for perturbed glycolysis

Obesity Pathogenesis - Effect of DHEA and 8-OH-DPAT on caloric intake investigated

Obesity Pathogenesis - Meltrin alpha plays role in development of white adipose tissue

Obesity Pathogenesis - Recent findings illuminate research in obesity pathogenesis

Obesity Therapy - Benzoxazinone derivatives for treatment of obesity synthesized

Obesity Therapy - Messages of fat cells define new approaches to treat obesity

Obesity Therapy - Weight loss increase skeletal muscle electron transport chain activity

Obesity and Diabetes - Anorexic effects of insulin reduced in obesity-prone rats

Olfaction - Olfactory receptors examined, characterization in baculovirus system reported

Olfactory Receptors - G-protein-coupled receptor orthologs studied, ubiquitous expression shown

Oncogenesis - Fatty acid metabolism regulates cancer cell survive in hypoxic environments

Oncology - Aberrant proteins are a hallmark of primary liver cancer progression

Oncology - Antibody gains rapid access to integrin overexpressed on tumor vessel lumina

Oncology - Antisense oligonucleotide-mediated hTERT inhibition hinders prostate cancer

Oncology - Damaged DNA-binding protein 2 plays a major role in resistance to apoptosis

Oncology - Findings describe new data in oncology research

Oncology - Maspin promotion limits tumor metastasis

Oncoproteins - PARP-10 analyzed, transformation inhibition demonstrated

Oral Cancers - Chingwaysan induced apoptosis in human oral cancer cell lines, OC2 and TSCCa

Orthopedics - Gene therapy holds promise for generating new bone growth

Ovarian Cancer - Agreement signed to evaluate proteomic system for ovarian cancer diagnostics

Pain Medicine - Study of human genome screen shows 5-LOXIN's anti-inflammatory effects

Papillomavirus - Rabbit papillomavirus oncoproteins associated with tumor suppressor

Patents - Company wins patent related to detection of mRNAs

Personnel - Automation provider selects director of scientific applications

Personnel - Biopharmaceutical hires VP pharmaceutical operations

Phagocytosis - Endoplasmic reticulum membrane examined, use for phagocytosis revealed

Pharmacokinetics - In vitro metabolism of oxazolidinedione hypoglycemic agent described

Pharmacology - Gram-negative endotoxins have differential effects on drug metabolism

Phosphorylation - Artemis analyzed, phosphorylation in response to DNA damage revealed

Physical Activity - Exercise has anti-inflammatory effects

Physical Activity - Exercise increases skeletal muscle vasodilatory responses in obese rats

Physical Activity - Exercise prevents hyperphagia and obesity in OLETF rats

Physiology -  Paracoccus pantotrophus studied, nature of dissimilation of cysteate defined

Physiology - LFA-1 analyzed, domain dissociation and global conformational changes shown

Physiology - Researchers provide details of new studies and findings in the area of physiology

Prolactin - Tandospirone studied, neuroendocrine and kinase signaling clarified

Prostate Cancer - Activation of p53/p21(Waf1/Cip1) pathway inhibited cell proliferation

Prostate Cancer - Heat shock protein expression elevated in aggressive tumors

Prostate Cancer - Zoledronic acid mediated ras-independent growth inhibition of prostate cancer

Protein C Inhibitor - Human protein C inhibitor expressed in E. coli characterized

Protein Expression - Esophageal cervical inlet patch studied, protein expression clarified

Protein Expression - Major vault protein examined, expression and proteasomal degradation defined

Protein Expression - Rainbow tags allow visualization of protein expression and purification

Protein Expression - Testicular development analyzed, CDK11(p58) expression defined

Protein Folding - Controlled oxidative protein refolding using ion-exchange reported

Protein Interactions - p53-DNA crystal structures analyzed, protein-protein interfaces compared

Protein Kinase - Alpha-dystrobrevin analyzed, association with reorganizing tight junctions shown

Protein Kinase - Mouse model studied, role of protein kinase A in weight loss clarified

Protein Kinase - Protein kinase C isoforms studied, reduction in developing brain revealed

Proteomics - Angiostatin and plasminogen share endothelial cell binding motifs

Proteomics - Biopharmaceutical companies enter into research, license and option agreement

Proteomics - Functional specificity of shuttling hnRNPs determined

Proteomics - Hepatitis C virus 4A and 4B proteins transactivate the interleukin 8 promoter

Proteomics - Major proteins antagonize VEGF receptor to control embryonic vessel formation

Proteomics - Myocardium examined, kinase targeting of sarcoplasmic reticulum clarified

Proteomics - Recent studies add new data to proteomics research

Proteomics - SMA model accurately describes ion exchange equilibrium of protein

Proteomics - Targeted aquaporin-1 gene disruption impairs cell migration and angiogenesis

Proteomics - Uncoupling protein studied, protection in ischemia-reperfusion injury revealed

Proteomics - VEGF may have a nuclear function in hypoxic environments

Pseudomonas Aeruginosa -  P. aeruginosa azurin folding examined, structure involvement clarified

Pulmonary Medicine - Anti-interleukin 8 therapy arrests inflammatory signals in airway cells

Pulmonary Medicine - Decoy oligodeoxynucleotides protect against septic acute lung injury in mice

Pulmonary Medicine - Mutations in Hupki murine fibroblasts resemble those in human lung tumors

Receptor Studies - Hypoglycemia induces kainic acid receptor mRNA changes

Reproductive Biology - Mouse model shows LPA receptors affect uterine implantation of embryos

Reproductive Biology - Placental ABCB1 and ABCG2 protect fetus from maternal xenobiotic intake

Reproductive Medicine - Androgen-regulated genes identified in mouse testis

Respiratory Syncytial Virus - G protein vaccine against RSV modulates protective immunity

Restenosis - Cilostazol downregulates transcription factor E2F

SARS Coronavirus - SARS CoV 3CL(pro) indispensable for proteolytic activity/not enzyme dimerization

Salmonellosis -  Salmonella surface components modulate inflammatory mediators

Skin Cancer - Cellular and molecular events led to development of skin cancer

Skin Cancer - Natural antioxidant from olive oil prevented protein damage from UV radiation

Smooth Muscle - Heat-shock response studied, link with interleukin-6 revealed

Spondyloarthropathies - BMP bumps up hope for joint diseases

St. John's Wort - St. John's wort induced a decrease in plasma concentration of P-glycoprotein

Statins - Octreotide can mimic ischemic PC to reduce infarct size

Superoxide - Rac2 analyzed, influence on innate immunity revealed

Synapses - Neuron synaptic efficacy and plasticity studied, role of ATP clarified

Synapses - Receptor-dependent long-term depression examined, developmental switch revealed

Systemic Lupus Erythematosus - A candidate biomarker may improve treatment of lupus patients

Systemic Lupus Erythematosus - High expression of interferon-induced genes associated with disease severity

T-Cell Large Granular Lymphocyte Leukemia - Epitope defined for HTLV env seroreactivity observed in LGL leukemia

Tamoxifen - Molecular changes associated with agonist activity of hydroxy-tamoxifen

Therapy - Longicalycinin A reported, role as cytotoxic cyclic peptide revealed

Thymosins - Roles of thymosins in cancers and other organ systems studied

Thyroid Cancer - Potential role of tumor macrophages in carcinoma physiology reported

Thyroid Gland - G-protein coupled receptor kinase examined, thyroid expression clarified

Tobacco Use - Short-term cigarette smoke exposure reduces body weight and appetite

Toxicity - Monochloramine toxicity on PC12 cells and tocopherol protection studied

Transcriptional Regulation - Polycomb group response element examined, effect on silencing defined

Trichinella Spiralis - Helminth regulation of host IL-4R alpha/Stat6 signaling described

Tuberculosis Vaccines - Studies describe new findings in tuberculosis vaccines research

Tuberin - G_i/o proteins examined, role in tuberin alteration revealed

Vaccine Efficacy - Peptide vaccine excludes antigen-specific T cells from splenic lymph

Vaccinia Virus - Role of endocytosis in vaccinia enveloped particles formation reported

Virology - New findings in virology described