Proteomics Weekly

Angiotensin - Urotensin II muscle myoblast receptors examined, characterization reported

Disease Associations -  Porphyromonas gingivalis examined, periodontal fimA genotypes clarified

Multiple Sclerosis - Myelin protein studied, sequential macrophage-mediated degradation revealed

Parkinson Disease - Parkin analyzed, effects of disease-linked point mutations revealed

Signal Transduction - Cutting edge: KIR2DL4 transduces signals into human NK cells

Adenovirus - Company introduces upgraded version of kit for adenovirus purification

Adenovirus - New findings in the area of adenovirus detailed

Adipogenesis - Alkaline phosphatase aids control of adipogenesis in preadipocyte cell line

Adipogenesis - New research in the area of adipogenesis detailed

Adverse Drug Reaction - DNA testing may reduce adverse drug reactions by 20-50%

Age-Related Macular Degeneration - Company announces approval of Macugen in Canada for neovascular AMD

Diabetes Pathogenesis - Researchers' findings advance diabetes pathogenesis research

Alzheimer Disease - Calsenilin overexpression examined, effect on gamma-secretase activity revealed

Alzheimer Disease - Findings in Alzheimer disease provide new insights

Alzheimer Disease - Prospects for disease-modifying therapy of Alzheimer disease outlined

Alzheimer Disease - Reduction of amyloid burden examined, role of docosahexaenoic acid revealed

Alzheimer Disease - Up-regulation of glutathione protects neurons against A-beta toxicity

Amyloid Beta - Somatostatin analyzed, brain amyloid beta peptide regulation clarified

Diabetes Pathogenesis - Researchers' work adds to diabetes pathogenesis body of knowledge

Amyloid Precursor Protein - FE65 adaptor protein studied, role in beta-amyloid load revealed

Amyotrophic Lateral Sclerosis - Amyotrophic lateral sclerosis studied, role of MMP-9 defined

Androgen Receptors - Epididymis caput epithelial cell line functionally characterized

Angiology - Calcium and Src family kinases examined, differential requirements identified

Angiology - LDL platelet-activating properties studied, effect of oxidation revealed

Angiology - New data illuminates research in angiology

Diabetes Therapy - Researchers publish new studies and findings in the area of diabetes therapy

Angiology - VEGF infusion protects against skeletal muscle ischemia/reperfusion injury

Angiotensin - Recent studies add new data to angiotensin research

Antidepressants - Neuroplasticity examined, changes in regulatory signaling revealed

Antimicrobial Compounds - Parotid secretory protein analyzed, expression in gingival keratinocytes shown

Antithrombins - Antithrombin analyzed, characterization of molecular defect reported

Apoptosis - Jurkat T cell apoptosis examined, myosin heavy chain-A cleavage revealed

Diabetes Therapy - Studies add new findings to diabetes therapy body of knowledge

Arthritis - Fibroblast-like synoviocytes examined, nature of p38 MAPK regulation clarified

Assisted Reproduction - Mifepristone prevents premature LH surges in women undergoing COH for IVF

Asthma Pathogenesis - Transfer of T-helper cell clones attenuates asthmatic phenotype

Astrocytoma - Human gliomas analyzed, differential protein expression revealed

Atherosclerosis - Atherosclerosis studied, role of reverse cholesterol transport genes defined

Immunology - Recent findings in immunology provide new insights

Atherosclerosis - Researchers' findings advance atherosclerosis research

Atherosclerosis - Serum amyloid A and lipoprotein retention in murine models of atherosclerosis

Axon Terminals - Presynaptic differentiation studied, T-cell role and kinase signaling defined

Bacteriology - Interactions may allow Salmonella to successfully evade immune system

Bacteriology - Mouse Paneth cell studied, secretory responses to pathogenic bacteria clarified

Bacteriology - Research aims to break down barriers in bacterial infection

Neurology - Researchers' data advance neurology research

Biomedical Engineering - Growth hormone maintains capillary growth elements in tissue culture models

Blood Coagulation - Factor H analyzed, cleavage by dermatan sulfate-mediated protease documented

Brain Cancer - Hypoxia drives glioma growth through signals that elicit angiogenesis

Brain Development - Non-testis-specific CABYR variants studied, characterization reported

Breast Cancer - HIV Tat targeted into mitochondria of breast cancer cells

Breast Cancer - P16 and its cytoplasmic sequestration is a feature of breast carcinoma

Oncology - Recent findings illuminate research in oncology

Breast Cancer - SPARC sways survival and tumor progression in breast cancer patients

Business & Finance - Developer of protein-based diagnostic products reports first quarter finances

Business & Finance - Melanoma-focused pharmaceutical company reports Q1 2005 financial results

Business & Finance - Research and development company announces financial results

COX-2 - New transcription-based strategy controls COX-2 overexpression and CV diseases

Cancer Drugs - P-glycoprotein function and expression inhibited by kaempferol and quercetin

Oncology - Recent findings in oncology provide new insights

Cancer Immunotherapy - Treatment combining interleukin-2 and radiotherapy treats scalp angiosarcoma

Cancer Therapy - FDA accepts Genentech's application to start skin cancer treatment phase I trial

Cancer Therapy - Studies describe new findings in cancer therapy research

Cancer Vaccines - Cancer immunotherapy targets minor histocompatibility antigens

Cancer Vaccines - New research in the area of cancer vaccines detailed

Cancer Vaccines - Role of CD4⁺ cells and antibodies in breast cancer protection described

Oncology - Research in oncology provides new insights

Cancer Vaccines - Tumor proteome suppressed by an adenovirus-based skin patch vaccine

Capsaicin - Capsaicin calcitonin peptide studied, role in myoelectrical activity revealed

Cardiology - Dual-gene vector aids myocardial gene expression evaluations in mice

Cardiology - Endotoxic shock examined, effects on rat cardiac myocytes elucidated

Cardiology - Reoxygenation examined, effect in hypoxic newborn pigs clarified

Cardiology - Studies add new findings to cardiology body of knowledge

Oncology - Researchers report details of new studies and findings in the area of oncology

Cardiology - c-Fos/AP-1 does not appear to be critical for cardiomyocyte hypertrophy

Cardiomyocyte - Post cell transplant cardiac function improves regardless of VEGF transfer

Cardiopulmonary Bypass - Endogenous antioxidant activity during CPB surgery characterized

Cardiovascular Disease - Adipose tissue is major production site of serum amyloid A

Cardiovascular Disease - Advanced glycation end product levels predict mortality in nondiabetic women

Cardiovascular Disease Risk Factors - High level of CRP is related to low ankle brachial index among Japanese

Proteomics - Studies add new findings to proteomics body of knowledge

Cell Biology - Abnormal cell division explained

Cell Biology - Endothelial cell counter-receptor fosters CD97-induced angiogenesis

Cell Biology - Faulty folding of protein in the environment may cause disease

Cell Development - Anaphase-promoting complex inhibitor studied, cytostatic factor arrest shown

Chagas Disease -  Trypanosoma cruzi-infected patients have varied antibody responses

Cholic Acid - Conversion of PrPC to PrPres analyzed, modulators described

Virology - Reports describe recent advances in virology research

Chronic Hepatitis C - Plasma adiponectin falls as steatosis rises in patients with hepatitis C

Clinical Trials - Clinical trials of blood test for HPV-associated cervical cancer are underway

Collaborations - Companies ally to manufacture plasmid DNA for trials and commercial supply

Collaborations - Companies ink joint development agreement to produce products from chloroplasts

Collaborations - Deal signed for Glycomics Solution for proteomics research

Collaborations - Epigenomics inks strategic collaboration in DNA methylation

Colon Cancer - IL-8 promotes cell proliferation in human colon carcinoma cells

Complementary and Alternative Medicine - Black nightshade isolate shows promise as cholesterol-lowering agent

Cone Photoreceptors - Retina of mice examined, impairments in the absence of a gated channel clarified

Coronary Artery Disease - Adipose tissue adiponectin expression low in coronary artery disease

Coronary Ectasia - MMP/TIMP imbalance may contribute to ectasia formation

Coronary Heart Disease - CLA-1 exon 8 gene polymorphism may be associated with CHD in males

Cystic Fibrosis - Company receives orphan drug designation for cystic fibrosis treatment

Cytotoxicity - Homopolymeric amino acid cytotoxicity examined, comparative analysis reported

DNA Vaccines - Researchers describe findings in DNA vaccines studies

DPT Vaccines - Studies advance knowledge in DPT vaccines research

Dementia - Manganese-induced prion aggregates studied, single particle analysis reported

Dengue Virus - Mutant dengue 2 viruses characterized

Dermatology - Natural angiogenesis inhibitors relocate to venous leg ulcers

Developmental Biology - Scientists reveal system of embryonic law and order

Developmental Biology - Study explains aging stem cell behavior

Diabetes Complications - VEGF overexpression creates primate models of diabetic retinopathy

Diabetes Genomics and Genetics - Endothelial nitric oxide synthase polymorphism linked to albuminuria

Diabetes Pathogenesis - Carboxypeptidase E aids processing of amyloid polypeptide in beta cells

Diabetes Pathogenesis - Glucagon-like peptide 1 in biology and pathology reviewed

Diabetes Pathogenesis - Influence of PPAR-gamma polymorphisms on insulin sensitivity described

Diabetes Pathogenesis - Researchers' data advance diabetes pathogenesis research

Diabetes Pathogenesis - Type 2 diabetes alters response of protein to nutritional deprivation

Diabetes Therapy - 11-Beta-hydroxysteroid dehydrogenase-1 is target for metabolic diseases

Diabetes Therapy - Gender-dependent effect of aging on insulin action examined

Diabetes Therapy - Prolonged insulin treatment inhibits hormone signaling

Diabetes Therapy - Research in diabetes therapy provides new insights

Diabetic Nephropathy - Impaired aldosterone response linked to hemodialysis in type 2 diabetes

Diabetic Nephropathy - Researchers' data advance diabetic nephropathy research

Diagnostics - Candidate proteins differentiate hepatitis B-related liver cancer

Diagnostics Imaging - Recent findings in diagnostics imaging described

Dicloxacillin - Effect of P-glycoprotein on dicloxacillin pharmacokinetics studied

Dictyostelium Discoideum -  Dictyostelium discoideum helical domain studied, mutations identified

Diet & Nutrition - Short-term starvation and refeeding studied, effects on muscle clarified

Diet & Nutrition - Vitamin D-3 deficiency in utero results in changes in adult rat brain

Disease Associations -  Legionella pneumophila antigens studied, macrophage processing clarified

Disease Associations -  Stachybotrys chartarum examined, lung inflammatory responses clarified

Disease Associations -  Staphylococcus aureus studied, role of prelipoprotein lipidation clarified

Disease Associations - Bacterial pathogens analyzed, secretion translocators and effectors clarified

Disease Associations - Pelizaeus-Merzbacher disease analyzed, premature myelin oligomerization shown

Disease Associations - Yersinia outer protein P studied, inhibition of CD8 T cell priming revealed

Drug Development - Preparative parallel protein purification reviewed

Drug Development - Tamoxifen-like drug suggests new ways to selectively block estrogen

Ebola Vaccine - CD8-mediated protection against Ebola infection is perforin dependent

Electrophoresis - Carrier ampholytes are potential buffers in electrophoresis

Electrophoresis - Novel micro-CE chip provides multiwavelength fluorescence detection

Endocrine - Intestinal metaplasia examined, endocrine cell co-existence described

Endocrinology - Differential effects estrogen and raloxifene signaling compared in rat uterus

Endocrinology - Growth factors affecting epithelial cell cytokine production studied

Endocrinology - Kappa-casein glycoforms examined, O-glycosylation site occupancy analyzed

Endocrinology - Reports describe recent advances in endocrinology research

Endotoxemia - Endotoxemia examined, cytokine and granulopoiesis responses clarified

Endotoxemia - Phospholipid emulsion neutralizes endotoxin in healthy volunteers

Enhanced Green Fluorescent Protein - Purification of EGFP using anion exchange chromatography reported

Epstein-Barr Virus - Research in epstein-barr virus provides new insights

Erythropoietin - Erythropoietin examined, effects on primary hippocampal neurons clarified

Escherichia Coli -  Escherichia coli cytolethal toxin studied, carbohydrate binding clarified

Finance - Biopharma reports Q1 net loss of $9.7 million

Finance - Biotechnologies holding company announces first quarter results

Finance - Drug-delivery company announces Q1 results, including milestone from TAP

Finance - Gene discovery biopharmaceutical company reports Q1 2005 financial results

Finance - HPV test maker reports increased revenues in third quarter

Finance - Implantable tissue company's Q1 revenues increase 17% over Q1 2004

Finance - Monoclonal antibody-focused biotechnology company reports Q1 2005 results

Finance - Pharmacogenomics company reports increased revenues in first quarter

Flavonols - Flavonols increase nuclear ER protein/decrease ERalpha protein of osteoclast SCs