Endotoxemia

Phospholipid emulsion neutralizes endotoxin in healthy volunteers

Published in Proteomics Weekly, May 30th, 2005

A phospholipid emulsion neutralized endotoxin in healthy volunteers.

"An approach to endotoxin (lipopolysaccharide [LPS]) blockade makes use of the ability of lipoproteins, via surface phospholipids, to bind and neutralize LPS. The aim of the present study was to determine whether the intravenous administration of a protein-free, phospholipid-rich emulsion is an effective method for neutralizing the effects of LPS in healthy persons. This was a double-blind, placebo-controlled study in 20 volunteers," investigators in the United States report.

"Volunteers received Escherichia coli endotoxin (2 ng/kg) intravenously 2 hours into a 6-hour...

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Source: Proteomics Weekly (2005-05-30)

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