Interleukin

Interleukin dimerization analyzed, role in neutrophil oxidant production shown

Published in Proteomics Weekly, May 30th, 2005

Recent research from the United States has reported on interleukin 8 (IL-8) dimerization as a mechanism for regulation of neutrophil adherence-dependent oxidant production.

"IL-8, a member of the CXC subfamily of chemoattractant cytokines, induces a range of functional responses in human neutrophils via its interactions with two high-affinity cell-surface receptors, CXCR1 and CXCR2. Like other CXC chemokines, IL-8 forms homodimers at physiologic concentrations. Monomers and dimers bind to CXC receptors with high affinity and induce various functions.

"Binding to glycosaminoglycans decreases the dimerization constant, enhancing surface-bound dimer...

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Source: Proteomics Weekly (2005-05-30)

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