Published in Proteomics Weekly, May 30th, 2005
"IL-8, a member of the CXC subfamily of chemoattractant cytokines, induces a range of functional responses in human neutrophils via its interactions with two high-affinity cell-surface receptors, CXCR1 and CXCR2. Like other CXC chemokines, IL-8 forms homodimers at physiologic concentrations. Monomers and dimers bind to CXC receptors with high affinity and induce various functions.
"Binding to glycosaminoglycans decreases the dimerization constant, enhancing surface-bound dimer...
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