Angiotensin

Urotensin II muscle myoblast receptors examined, characterization reported

Published in Proteomics Weekly, May 30th, 2005

Recent research from the United States published in the journal Peptides reported the characterization of functional urotensin II (U-II) receptors in human skeletal muscle myoblasts (HSMM).

"The properties of U-II receptor (AT receptor) and angiotensin II (ANG II) receptor (AT receptor) in primary HSMM and differentiated skeletal myotubes (HSMMT) were characterized," wrote J.S. Qi and colleagues, Johnson & Johnson Pharmaceutical Research & Development LLC.

"Radiolabeled U-II and ANG TI bound specifically to HSMM with K-d's of 0.31 nM (2311 receptors/cell) and 0.61 nM (18,257 receptors/cell), respectively. The cyclic segment of U-II peptide,...

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Source: Proteomics Weekly (2005-05-30)

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