Malaria

Prostaglandin E-2 production impaired in children with cerebral malaria

Published in Proteomics Weekly, May 30th, 2005

Systemic production of prostaglandin E-2 is impaired in children with cerebral malaria.

According to a study from the United States and Australia, "Prostaglandins (PGs) are important mediators of macrophage activity, vascular permeability, fever, erythropoiesis, and proinflammatory responses to infection. Our recent studies have shown that plasma levels of bicyclo-PGE₂ (a stable end product of PGE₂ metabolism) and leukocyte cyclooxygenase (COX)-2 gene expression are suppressed in children with malarial anemia. Since the role of PGs as immunomodulators of human cerebral malaria (CM) has not been examined, we investigated urinary levels of...

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Source: Proteomics Weekly (2005-05-30)

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