Multiple Sclerosis

Myelin protein studied, sequential macrophage-mediated degradation revealed

Published in Proteomics Weekly, May 30th, 2005

Research from the Netherlands has reported on the determination of the sequential macrophage degradation of myelin proteins.

"Demonstration of different myelin proteins (myelin basic protein [MBP], proteolipid protein [PLP] and myelin oligodendrocyte glycoprotein [MOG]) is used as a tool to determine the stage of MS lesions in autopsy tissue. Since such tissue can never be obtained at well-defined stages of lesion formation, the time course of myelin degradation in MS lesions can only be estimated.

"In order to obtain a more precise indication on the sequence of events of myelin degradation in MS lesions, the breakdown of human myelin by human...

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Source: Proteomics Weekly (2005-05-30)

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