Proteomics Weekly
Susan Hasty, Publisher
Table of Contents . . . July 4th, 2005
Non-Subscriber - Summaries OnlyRelated Areas: Other Issues in Proteomics Weekly | Other Publications
Acetaminophen - Fever control in septic shock examined, benefit or harm probed
Androgen Receptors - Androgen receptor associated protein examined, prostate expression defined
Disease Associations - Sickle red blood cell adhesion to laminin studied, role of Rap1 defined
Neuroscience - Human tumorous imaginal disc studied, neurite outgrowth defined
Transgenics - Alzheimer disease modeled, beta-amyloid probe imaged
Actin - Actin cytoskeleton studied, differentially platelet regulation clarified
Acute Coronary Syndrome - Study investigated association of alleles M280 and 1249 of CX3CR1 with CAD
Acute Lung Injury - COX-2-derived products play key roles in resolution
Addiction Medicine - Neuropeptide Y polymorphism associates with alcohol dependence
Adrenoceptors - Neocortical and visuo-spatial activities studied, effect of malnutrition shown
Adrenocortical Tumors - Chromosome 17 mutations linked to adrenocortical tumors
Alzheimer Disease - Recent findings in Alzheimer disease provide new insights
Aging - Carrageenan-induced acute lung inflammation studied, effect of age revealed
Aging - Senile seminal vesicle amyloid analyzed, semenogelin derivation revealed
Allergy Medicine - Anti-allergen IgE antibodies studied, quantitative measurement reported
Allergy Medicine - Atopic asthma examined, increase in killer-specific secretory protein shown
Allergy Medicine - Fungal fragments and conidia studied, role as aeroallergens revealed
Allergy and Immunology - CD28 signals stabilize epigenetic modifications of interleukin-2 promoter
Atherosclerosis - Studies describe new findings in atherosclerosis research
Alzheimer Disease - Bioscience company describe new in-cell western assay in published paper
Alzheimer Disease - Calmyrin examined, altered distribution in Alzheimer forebrain revealed
Alzheimer Disease - Company files new drug application for compound to treat Alzheimer disease
Alzheimer Disease - Recent findings in Alzheimer disease described
Alzheimer Disease - Variant prion protein causes infection but no symptoms
Cancer Vaccines - New findings in cancer vaccines described
Amyloid Protein - Amyloid beta protein production studied, nature of LRP enhancement defined
Amyloid Protein - Amyloid proteolysis analyzed, disparate roles of cathepsin B and L revealed
Angiology - Enriched genes aid aortic adaptation to biomechanical stress
Angiology - Researchers provide details of new studies and findings in the area of angiology
Animal Models - Humanized ABCA1 murine model developed
Anorexia Nervosa - Leptin regulation in children with anorexia nervosa investigated
Cancer Vaccines - New research in the area of cancer vaccines detailed
Antidepressants - Hyperforin activates nonselective cation channels (NSCCs)
Antigens - Antigen presentation analyzed, role of antigen presentasome clarified
Antimicrobials - Antimicrobial peptide rCRAMP studied, central nervous system location revealed
Antioxidants - Gingival fibroblasts studied, role of nicotine in heme oxygenase shown
Antioxidants - Interaction between M. truncatula and S. meliloti reported
Apoptosis - Mesangial cell apoptosis analyzed, signaling and apoptotic events clarified
Cancer Vaccines - Research add new data to cancer vaccines body of knowledge
Apoptosis - Neuronal apoptosis examined, oxidative damage and defective DNA repair revealed
Apoptosis - Osteoclasts studied, functional influence of stromal cell-derived factor shown
Apoptosis - T lymphocyte arrest and apoptosis analyzed, influences of burn injury clarified
Arthritis - Hyaluronan affected inflammatory cytokines in knee osteoarthritis
Arthritis - Scientists show how arthritis is transferred throughout the body
Assisted Reproduction - Researchers' findings advance assisted reproduction research
Cancer Vaccines - Researchers' data advance cancer vaccines research
Astrocytes - Astrocyte density examined, alcohol abuse-related differences revealed
Atherosclerosis - New findings in atherosclerosis described
Autoimmune Disease - IL-27 subunits and receptor studied, nature of pathogenic regulation defined
Avian Influenza - Biomanufacturing company reports progress of avian transgenics project
Bacteriology - Stress survival examined, role of Staphylococcus aureus ClpYQ defined
Cancer Vaccines - Studies add new findings to cancer vaccines body of knowledge
Basal Cell Carcinoma - Company doses first patient in phase I clinical trial for basal cell carcinoma
Biomedical Engineering - Biotechnology company to offer device to enhance de novo peptide sequencing
Biomedical Engineering - Self-assembling genetically engineered hydrogels have biomedical potential
Biosynthetics - Prostaglandin biosynthetic pathway markers augment lung cancer angiogenesis
Bladder Cancer - Co-expression of RON and MET prognosticated transitional-cell carcinoma
Blood Cancer - Trial of second-generation Hsp90 inhibitor in hematologic cancers initiated
Cardiology - Reports advance knowledge in cardiology research
Brain Cancer - Brain tumors examined, aquaporin and K+ channel redistribution clarified
Brain Cancer - DNA-dependent protein kinase blockade triggers autophagy in irradiated cells
Brain Cancer - Endoglin is a better marker of glioblastoma angiogenesis than CD31
Breast Cancer - Clinical trial to evaluate vaccine made from patient's dendritic cells
Breast Cancer - DNA vaccination/BAT combo protects against incipient carcinomas
Breast Cancer - Findings describe new data in breast cancer research
Cardiology - Research add new data to cardiology body of knowledge
Business & Finance - Biosciences corporation announces second quarter financial results
Business & Finance - GlaxoSmithKline makes milestone payment, begins thrombocytopenia drug trial
Business Update - Company announces agreement to promote Alcortin and Novacort to dermatologists
Business Update - World's largest polymerase chain reaction manufacturing facility dedicated
Calcitonin Receptors - Calcitonin gene-related peptide receptor studied, presence and function defined
Cancer Research - Research on apoptosis in cancer cell discussed
Diabetes Pathogenesis - Research in diabetes pathogenesis provides new insights
Cancer Therapy - New regulators of apoptosis and chemoresistance identified
Cancer Therapy - SJ-8026 amplifies tumor apoptosis and halts angiogenesis
Cancer Therapy - Tyrosine kinase inhibitor AZD2171 subdues tumor angiogenesis
Cancer Vaccine - DNA vaccine plus IL-12 enhances anti-angiogenic and antitumor effects
Cancer Vaccines - Findings describe new data in cancer vaccines research
Diabetes Pathogenesis - Studies add new findings to diabetes pathogenesis body of knowledge
Carcinogenesis - Vitamin K-2 and perindopril combine to attenuate preneoplastic liver lesions
Carcinogenesis - WNT-1 implicated in tumor differentiation in oral squamous cell carcinoma
Diabetes Therapy - New findings in the area of diabetes therapy described
Cardiology - Reports add new data to cardiology research
Cardiovascular Research - Hcy levels and GPx-1 activity identify individuals at high CV risk
Cell Biology - Coupling prototypes predict VEGF isoform behavior in human pathology
Cell Biology - Immune cells' genetic "jam session" is controlled by cell division machinery
Diabetes Therapy - Researchers' work adds to diabetes therapy body of knowledge
Cell Cycle - Mnt-Max to Myc-Max complex switching studied, cell cycle regulation defined
Chaperonins - GroEL studied, chaperonin activity at heat-shock temperature revealed
Chlamydia Pneumoniae - Chlamydia pneumoniae Cpn0796 examined, nature of secretion defined
Chlamydia Vaccines - Researchers' work adds to chlamydia vaccines body of knowledge
Clinical Studies - Study demonstrating immunomodulatory activity in dogs presented
Collaborations - Alliance to deliver proteomic solutions for biomarker discovery, validation
Disease Associations - Studies advance knowledge in disease associations research
Collaborations - Clemson to collaborate on the development of enzymes to enhance human nutrition
Collaborations - Collaboration announces breakthrough in avian transgenic biomanufacturing
Collaborations - Diagnostic biomarker collaboration with Ortho-Clinical Diagnostics launched
Collaborations - Therapeutics companies establish alliance to develop monoclonal antibodies
Colon Cancer - Claudin-1: a potential biomarker for colon cancer progression
Colon Cancer - Collaboration to focus on the role of DNA in colon cancer detection
Endocrinology - New research in the area of endocrinology detailed
Colon Cancer - Researchers' findings advance colon cancer research
Coronary Artery Disease - MMP-9 and MMP-2 might be markers of plaque rupture or instability
Cotransporters - Intestinal Ca2+ uptake examined, influence of NaCl-cotransporter clarified
Crohn Disease - NOD2-associated Crohn disease studied, receptor sensitivities clarified
DNA Research - Researchers explain mechanisms of immune responses induced by DNA vaccines
Hormones - Studies add new findings to hormones body of knowledge
Dengue Fever - DIII can be use as tetravalent DNA formulation to induce antibodies
Dental Health - Dental microbiota studied, phenotypic and genotypic selection defined
Developmental Biology - MicroRNA tweaks protein that controls early heart development
Diabetes Pathogenesis - Glucagon-like peptide-1 contributes to maintaining beta-cell function
Diabetes Pathogenesis - Group IIA secreted phospholipase A(2) linked to early changes in nephropathy
Diabetes Pathogenesis - JNK protein kinases have important role in diabetes
Hypertension - Recent findings in hypertension provide new insights
Diabetes Pathogenesis - Reports describe recent advances in diabetes pathogenesis research
Diabetes Therapy - New data illuminates research in diabetes therapy
Hypertension - Reports describe recent advances in hypertension research
Diabetic Glomerulosclerosis - Glutathione peroxidase is decreased in DGS patients
Diabetic Nephropathy - Reports describe recent advances in diabetic nephropathy research
Diagnostics - Company launches Deep Proteome Research Services
Diagnostics - Researchers publish new studies and findings in the area of diagnostics
Diet & Nutrition - Duodenal neuronal population studied, influence of hypoproteic ration defined
Diet & Nutrition - Study: Almonds reduce inflammation
Immunology - Findings advance knowledge in immunology research
Diffuse Brain Injury - Changes in metabotropic glutamate receptor expression characterized
Disease Associations - Enterococcus faecalis examined, persistence in aquatic environments defined
Disease Associations - Glycogen synthase kinase examined, disease roles clarified
Disease Associations - Reports advance knowledge in disease associations research
Disease Associations - Salmonella studied, influence of kinesin recruitment defined
Disease Associations - Streptococcus superantigens studied, host modulation revealed
Immunology - Reports advance knowledge in immunology research
Dopamine Receptors - Dense core vesicle release studied, protein-receptor regulatory role revealed
Drug Resistance - Multidrug resistance protein analyzed, functional interactions clarified
Dyslipidemia - Dietary constituents are associated with immune response to HSPs
Enamel - Rat enamel analyzed, presence of RP59 revealed
Endocrinology - Aldosterone deficiency examined, adrenal cortex homeostatic responses revealed
Oncology - Recent findings in oncology provide new insights
Endocrinology - Cystic fibrosis studied, nature of mucin glycosylation changes clarified
Endocrinology - Findings in endocrinology provide new insights
Endocrinology - Interactions of Pax8 and TTF-1 inaugurate thyroid specific gene expression
Endocrinology - UCLA study shows dosing regimen of hormone improves short stature in children
Endocytosis - Actin dynamics examined, nature of coupling to membrane trafficking defined
Oncology - Research in oncology provides new insights
Enteric Neurons - Neural-crest-derived cells examined, location and phenotype in mouse gut shown
Enzymology - Heat shock protein helps gene-directed enzyme prodrug therapy manage tumors
Enzymology - Non-denaturing 2D electrophoresis improves analysis of organelle enzymes
Enzymology - Researchers provide details of new studies and findings in the area of enzymology
Ephedrine - Ephedrine detection examined, receptor-based optical spot test developed
Epstein-Barr Virus - Recent studies add new data to epstein-barr virus research
Oncology - Researchers detail new studies and findings in the area of oncology
Exercise - Carbohydrates increase neutrophils and cortisol after intense exercise
Exocytosis - CTLA-4 exocytosis analyzed, nature of dependence and activation revealed
Ezrin - Ezrin oligomers studied, prevalence in gastric parietal cells established
Finance - Proteomics company receives equity investment from Quest Diagnostics
Gastric Cancer - ROS stimulates cell invasiveness of human gastric cancer AGS cells
Gastroenterology - Aquaporin examined, subcellular redistribution in Brunner's gland revealed
Proteomics - Researchers provide details of new studies and findings in the area of proteomics
Gastroenterology - CCK and GLP-1 studied, role of interactions in healthy men clarified
Gene Research - Data from meeting of the American Society of Gene Therapy highlighted
Gene Research - Nuclear receptor interaction protein augments cancer cell transcription
Gene Silencing - Research add new data to gene silencing body of knowledge
Gene Therapy - Company reports on DNA drug delivery for brain and eye diseases
Genetics & Genomics - Alternative splicing suggests extended function of PEX26
Proteomics - Researchers report details of new studies and findings in the area of proteomics
Genetics & Genomics - DNA-focused pharma to provide pharmacogenetic support to INC Research
Genetics & Genomics - Genetic switch for maturation discovered
Genetics & Genomics - Illumina launches SNP assay panels for fine mapping genetic variants
HIV/AIDS Pathogenesis - SP1 affects HIV-1 Gag-membrane binding and subsequent events of virus assembly
HIV/AIDS Pathogenesis - Studies describe new findings in HIV/AIDS pathogenesis research
HIV/AIDS Research - CTIP2 represses initial phase of HIV-1 gene transcription in microglial cells
Proteomics - Studies advance knowledge in proteomics research
HIV/AIDS Research - GEP inhibits HIV-1 transcription via Tat without directly binding to cyclin T1
HIV/AIDS Research - Mutant HIV dimeric RNA has same stability/conformation as wild-type RNA dimers
HIV/AIDS Vaccines - Researchers detail new studies and findings in the area of HIV/AIDS vaccines
Head and Neck Cancer - The new Myc-target gene mimitin stimulates esophageal cancer proliferation
Heart Failure - PDE5 inhibition with sildenafil improves cardiac output
Hematology - Researchers report details of new studies and findings in the area of hematology
Hepatitis B Virus - RNAi therapeutics company publishes hepatitis B virus data in 'Hepatology'
Hepatology - Adiponectin may be a cholestasis marker in chronic liver disease
Herpesvirus - LIGHT signaling analyzed, immune consequences defined
High Cholesterol - Study shows Docosahexaenoic acid lowered triglycerides and bad cholesterol
Hodgkin Lymphoma - Receptor tyrosine kinases linked to classic Hodgkin lymphoma
Hormones - Progesterone-binding protein studied, expression and up-regulation clarified
Hormones - Research add new data to hormones body of knowledge
Human Papillomavirus - Ability to mass produce HPV may lead to gains against cervical cancer
Hypertension - New findings in the area of hypertension described
Hypoxia - Hypoxia-inducible factor studied, role in erythroid progenitor motility defined
Immunology - CD22 binding captured
Immunology - Data advance knowledge in immunology research
Inflammatory Response - Effects of volumetric vs. pressure-guided fluid therapy compared
Information Technology - Co-marketing agreement signed to use proteomics kits in mass spectrometry
Information Technology - Solution launched for quantitative proteomics
Insulin Resistance - Adipocytes with increased hexosamine flux exhibit insulin resistance
Insulin Resistance - Adiponectin expression augments muscle insulin sensitivity in male rats
Insulin Secretion - Akt2 needed for calorie restriction effect on glucose uptake
Integrase - HIV-1 integrase-interaction domain studied, chromatin tethering revealed
Intrauterine Growth Restriction - Dexamethasone use in early pregnancy poses IUGR risk
Ischemia - Combined treatment reduces ischemia/reperfusion injury
Kidney Disease - Scientists confirm link between PKC enzyme and kidney disease in diabetes
Leptin Studies - Ventricular leptin decreases protein and fat in self-selecting rats
Lipoproteins - Vibrio vulnificus cytolysin studied, lipoprotein inactivation defined
Lipoproteins - Generation and function of astroglial lipoproteins reported
Lipoproteins - In vivo isolation of very low density lipoprotein phospholipids reported
Lipoproteins - Lipoprotein aggregation studied, macrophage cytotoxic protection documented
Lipoproteins - Lipoprotein metabolism studied, effect or receptor deficiencies defined
Lipoproteins - Researchers describe findings in lipoproteins studies
Machado-Joseph Disease - Lamotrigine therapy can reduce gait disturbance
Macrophages - Kv beta subunit expression and mode in macrophages studied, activation required
Matrix Metalloproteinase - Matrix metalloproteinase studied, role in surfactant protein-D regulation shown
Medical Devices - Protein crystal screening system launched
Medical Devices - TriVersa NanoMate launched for mass spectrometry
Melanocortin Receptors - Melanocortin receptors examined, multiple receptors revealed in bone cells
Melanoma Vaccine - Particulate structures of polyomavirus protein used to treat melanoma
Meningitis Vaccines - Findings in meningitis vaccines provide new insights
Metabolic Syndrome - PPAR-gamma knock-in mouse exhibits features of metabolic syndrome
Microencapsulation - Chitosan-coated microspheres produced via emulsification/internal gelation
Monoclonal Antibodies - Researchers reveal second binding site for Gas6-receptor interaction
Mucosa - Mucosal adaptation to enteral nutrients studied
Multiple Myeloma - Data on protein 90 inhibitor from clinical trials in multiple myeloma presented
Natural Killer Cells - Functional requirements for signaling through NK cell receptors studied
Neisseria - Neisseria PilC adhesin studied, binding specificities and host receptor defined
Neural Receptors - Muscarinic M-3 receptor dimer studied, role of paired activation defined
Neurodegenerative Diseases - Molecular zipper may hold important clues to Alzheimer, Parkinson and mad cow
Neuroprotection - Neural tube defects examined, peptide-mediated protection revealed
Neuroscience - Angiogenic proteins outline the course of brain arteriovenous malformations
Neuroscience - Neuronal AMPA receptors analyzed, molecular constituents defined
Neuroscience - Nicotine differentially affects neurotransmitter-regulating nAChRs
Neuroscience - Studies add new findings to neuroscience body of knowledge
Neurotensin - Neurotensin studied, stimulation of interleukin-8 expression revealed
Neurotransmission - Inhibition of transmitter release studied, role of bradykinin defined
Obesity Complications - Adenosinergic modulation of ventilation impaired in obese Zucker rats
Obesity Genomics and Genetics - Alleles on rat chromosome 4 regulate subphenotypes of obesity
Obesity Therapy - Islet amyloid polypeptide regulates energy homeostasis
Obstetrics - Researchers describe findings in obstetrics studies
Oncogenesis - Transcription factor Spz1 exhibits proto-oncogene activity
Oncology - Agents targeting KIT exon 8 mutations may treat core-binding factor leukemia
Oncology - Ephrin-A1 causes poor outcomes in alpha-fetoprotein-producing liver cancer
Oncology - New findings in the area of oncology described
Osteogenesis - Local transforming growth factor-beta strengthens bone regeneration
Ovarian Cancer - Introgen's INGN 241 activates tumor selective cell death pathways
Ovarian Cancer - Missing receptor molecule causes tumor growth
Ovarian Cancer - Social support linked to prognostic marker for ovarian cancer
Pain - NMDA receptor examined, function in pain-related synaptic plasticity defined
Pancreatic Cancer - New advances may slow tumor growth in pancreatic cancer
Pancreatic Cancer - Novel anti-pancreatic cancer agent LY293111 discovered
Parkinson Disease - Researchers create way to generate brain cells in lab
Patents - U.S. patent application filed on transrenal DNA-based HIV detection test
Pathogenesis - Dysplasia and hemimegalencephaly studied, molecular pathogenesis defined
Peritoneal Dialysis - CA125 examined, limitations as an index of peritoneal mesothelial mass shown
Personnel - Biotechnology company announces senior management change and relocation
Personnel - Drug process development company appoints William Haseltine advisor to board
Polyamines - Polyamines studied, role in synthesis and stability of occludin protein defined
Prions - Findings in prions provide new insights
Prions - Scrapie analyzed, PrPSc propagation with different PrP genotypes defined
Prions - Ure2p prion protein analyzed, filament cross-beat core structure revealed
Product Licensing - DNA-focused biopharmaceutical company licenses 3 cancer vaccine targets to Merck
Prolactin - Potential clinical uses of human prolactin receptor antagonists studied
Prostate Cancer - Exposure to sunlight may decrease risk of prostate cancer
Prostate Cancer - Functional role of MIM implicated in prostate cancer cell biology
Protease - Carboxypeptidases cathepsin X and B displayed distinct protein profiles
Protease - Prosubtilisin E autoprocessing studied, role of tryptophan residues defined
Protein Expression - ABCA2 protein expression in vestibular schwannoma and peripheral nerves shown
Protein Phosphorylation - Thrombin-stimulated human platelets analyzed, tyrosine phosphorylation evident
Protein Signaling - Galanin receptor regulation studied, role and action signaling clarified
Protein Synthesis - Pendrin overexpression studied, effects clarified
Protein Trafficking - E-cadherin polarized trafficking analyzed, regulation defined
Proteomics - Corporation expands proteomics capabilities with mass spectrometry systems
Proteomics - Genetic screening provider launches BioXPRESSION Biomarker
Proteomics - Protein expression data analysis system for mass spectrometry discovery launched
Proteomics - Researchers describe findings in proteomics studies
Proteomics - Study to evaluate PhosphoScan platform
Proteomics - Ultrasound method can augment organ-specific delivery of proteins
Psoriasis - Tumor necrosis factor enzyme studied, overexpression in psoriasis observed
Pulmonary Medicine - Daptomycin examined, inhibition by pulmonary surfactant revealed
Pulmonary Medicine - Select VEGF isoforms encourage pulmonary adenocarcinoma metastasis
Recombinant Research - A new vector system eases DMBT1 variant and full-length cloning
Renal Cancer - Gastrin releasing peptide receptor modulates angiogenesis and tumor growth
Renal Epithelium - Epithelial ATPase detachment studied, heat shock protein modulation revealed
Rheumatoid Arthritis - Data from Rituzan rheumatoid arthritis trial announced
Rheumatology - Angiopoietin-like-4 mediates angiogenic processes in arthritic tissues
SARS - UIC developing drug for SARS
SARS Coronavirus - Findings describe new data in SARS coronavirus research
Signaling Pathways - Intestinal fructose transport studied, role of signaling pathway clarified
Smallpox Vaccines - Recent findings in smallpox vaccines provide new insights
Smooth Muscle - Smooth muscle alpha-actinin examined, interaction with smitin revealed
Stem Cell Research - Increased Cux-1 expression may play role in activation of hepatic stem cells
Streptococcus Pneumoniae - Streptococcus pneumoniae studied, defect in mucociliary clearance revealed
Surfactant Protein - Surfactant protein studied, effect on lung function and air space defined
Synapses - Spinal cord injury examined, beneficial synaptic role of exercise clarified
T Cells - T cell-specific adapter protein studied, role in Lck activity shown
T Cells - U1A protein analyzed, T-cell epitopes identified
Telangiectatic Focal Nodular Hyperplasia - Molecular features and morphology of hepatic TFNH determined
Tetanus Vaccine - Single dose tetanus vaccine formulation developed
Tissue Engineering - Osteoblast growth and differentiation enhanced on peptide hydrogel
Transgenics - Osmotic-response element-binding protein studied, role in lens clarified
Transporters - Creatine transporter analyzed, purification and characterization reported
Vasculitis - Feline infectious peritonitis analyzed, granulomatous vasculitis clarified
Vector Development - Bifidobacterium infantis transmits suicide gene therapy to melanoma cells
Vector Development - Calcium strengthens plasmid-lipid particle transfection
Vesicles - Phospholipid vesicles studied, interference with antibody fragment binding shown
Vesicular Transport - ORP1S analyzed, role of region in the regulation of vesicular transport defined
Vibrio Cholerae - V. cholerae AphA is member of winged helix transcription factor superfamily
Virology - Adenovirus vector E4 regulates endothelial cell connexin expression
Visceral Leishmaniasis - A heterologous prime-boost vaccination strategy is efficacious
Wound Care - Vascular endothelial growth factor antagonism disrupts wound healing
Wound Healing - Fibrin clot adhesion examined, success of protein-conditioned dentin reported
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