Disease Associations

Sickle red blood cell adhesion to laminin studied, role of Rap1 defined

Published in Proteomics Weekly, July 4th, 2005

A study from the United States has defined the role of Rap1 in promoting sickle red blood cell (SS RBC) adhesion to laminin.

"Vaso-occlusion is a hallmark of sickle cell disease. Agonist-induced activation of SS RBCs promotes their adhesion to vascular proteins, potentially contributing to vasoocclusion," wrote M.M. Murphy and colleagues, University of North Carolina.

"Previously, we described a cyclic adenosine monophosphate (cAMP)-dependent increase in SS RBC adhesion to laminin. Here, we investigated whether Rap1, a small guanosine triphosphatase (GTPase) known to promote integrin-mediated adhesion in other cells, was involved in this signaling...

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Source: Proteomics Weekly (2005-07-04)

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