Neuroscience

Human tumorous imaginal disc studied, neurite outgrowth defined

Published in Proteomics Weekly, July 4th, 2005

According to research published from Canada, human tumorous imaginal disc 1 (TID1) associates with Trk receptor tyrosine kinases and regulates neurite outgrowth in nnr5-TrkA cells.

"The TID1 proteins including TID1_L and TID1_S , members of the DnaJ domain protein family, are involved in multiple intracellular signaling pathways such as apoptosis induction, cell proliferation, and survival. Here we report that TID1 associates with the Trk receptor tyrosine kinases and regulates nerve growth factor (NGF)-induced neurite outgrowth in PC12-derived nnr5 cells," wrote H.Y. Liu and colleagues, John P. Robarts Research Institute.

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Source: Proteomics Weekly (2005-07-04)

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