Vaccine Delivery

Delivery method for oligonucleotides developed in nephrectomy model

Published in Proteomics Weekly, September 26th, 2005

Researchers have developed a delivery method for oligonucleotides using a topical hydrogel tissue sealant in a murine partial nephrectomy model.

"Ischemia/reperfusion injury is a leading cause of renal damage and antisense gene therapy has been shown to ameliorate its effects. However, this approach has been limited by current delivery methods that require high concentrations of intravenous nucleic acids lacking specificity for targeting tissues. To overcome these limitations we developed a novel murine partial nephrectomy model to evaluate polyethylene-glycol (PEG) hydrogel tissue sealant as a topical oligonucleotide delivery system," scientists in the United States...

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Source: Proteomics Weekly (2005-09-26)

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