Physiology

p47phox-dependent NADPH oxidase regulates flow-induced vascular remodeling

Published in Proteomics Weekly, November 7th, 2005

According to a study from France, p47phox-dependent NADPH oxidase regulates flow-induced vascular remodeling.

"Chronic alterations in blood flow elicit an adaptive response that tends to normalize shear stress, involving nitric oxide (NO) and matrix metalloproteinases (MMPs)," wrote Y. Castier and colleagues, INSERM Centre de Recherche Cardiovasculaire Lariboisiere.

"To evaluate the role of NADPH oxidase in this process, we developed a new model of mouse arteriovenous fistula (AVF) connecting the right common carotid artery (RCCA) with the jugular vein, which does not affect blood pressure.

"Mice deficient for gp91phox and p47phox...

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Source: Proteomics Weekly (2005-11-07)

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