Cell Biology

Hypoxia regulates ephrins and angiogenesis in murine skin

Published in Proteomics Weekly, November 7th, 2005

Hypoxia regulates ephrins and angiogenesis in murine skin.

"Eph receptor tyrosine kinases and their ligands (ephrins) are key players during the development of the embryonic vasculature; however, their role and regulation in adult angiogenesis remain to be defined. Both receptors and ligands have been shown to be up-regulated in a variety of tumors," scientists in Switzerland report.

"To address the hypothesis that hypoxia is an important regulator of Ephs/ephrins expression, we developed a mouse skin flap model of hypoxia," said M.M. Vihanto and colleagues, University of Bern.

"We demonstrate that our model truly represents...

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Source: Proteomics Weekly (2005-11-07)

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