Coagulation

Human megakaryocytes process plasma factor V into alpha-granules

Published in Proteomics Weekly, November 7th, 2005

Recent research from Canada has clarified endocytosis and storage of plasma factor V by human megakaryocytes.

"Factor V is an essential coagulation cofactor that circulates in plasma and platelet alpha-granules where it is stored complexed to multimerin I (MMRNI). To gain insights into the origin and processing of human platelet factor V, and factor V-MMRNI complexes, we studied factor V in cultured megakaryocytes," wrote Y. Suehiro and colleagues, McMaster University.

"Factor V mRNA was detected in all megakaryocyte cultures. However, like albumin, IgG and fibrinogen, factor V protein was detectable only in megakaryocytes cultured with exogenous...

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Source: Proteomics Weekly (2005-11-07)

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