Complementary & Alternative Medicine

Indirubin promotes neutrophilic differentiation of human myelocytic leukemia cells

Published in Proteomics Weekly, November 7th, 2005

According to research published from Japan, indirubin promotes neutrophilic differentiation of human myelocytic leukemia cells.

"Indirubin, a purple vegetable dye, is a traditional Chinese medicine for myelocytic leukemia. Indirubin inhibits cyclin-dependent protein kinases (CDKs) and is present in human urine and serum," wrote K. Suzuki and colleagues, National Institute of Health Science.

"When indirubin was present during the neutrophilic differentiation of human myelocytic leukemia HL-60 cells, it augmented superoxide production triggered by opsonized zymosan (OZ) by the terminally differentiated HL-60 cells. It also augmented the calcium...

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Source: Proteomics Weekly (2005-11-07)

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