Proteomics Weekly
Susan Hasty, Publisher
Table of Contents . . . November 14th, 2005
Non-Subscriber - Summaries OnlyRelated Areas: Other Issues in Proteomics Weekly | Other Publications
Apoptosis - Ceramide activates a mitochondrial p38 mitogen-activated protein kinase
Proteomics - Chaperone-like activity of MTB Hsp16.3 does not require its intact structures
Proteomics - P-gp expression, but not BCRP, upregulated in early pregnancy to protect fetus
Proteomics - Proteomics of rheumatology are analyzed
Allergy & Immunology - Mnks role in cytokine regulation indicates value as new anti-inflammatory target
Allergy Medicine - Recent findings in allergy medicine provide new insights
Alzheimer Disease - Findings in Alzheimer disease provide new insights
Aneurysms - Decreased expression of fibulin-5 correlates with reduced elastin in thoracic aortic dissection
Angiology - C-reactive protein elevation correlates with accelerated atherogenesis in rheumatoid arthritis
Angiology - Researchers provide details of new studies and findings in the area of angiology
Cancer Therapy - Recent findings illuminate research in cancer therapy
Angiotensin - Simvastatin therapy normalizes sympathetic neural control in experimental heart failure
Anorexia Nervosa - Adiponectin levels not linked to changes in fat mass or BMI in anorexia
Anthrax Vaccine Development - Monoclonal antibody protects against anthrax toxin
Apoptosis - Alpha-tocopheryl succinate selectively induced apoptosis in neuroblastoma cells
Apoptosis - Anti-apoptotic and malignancy-causing protein Mcl-1 inhibited mitochondrial Ca2+ signals
Apoptosis - Downregulation of survivin diminishes radioresistance of pancreatic cancer cells
Cancer Vaccines - New findings in the area of cancer vaccines described
Apoptosis - Glycolysis linked to apoptosis
Apoptosis - Reports advance knowledge in apoptosis research
Assisted Reproduction - Chromosomal abnormalities found in pregnancies conceived with technologies
Asthma - Studies add new findings to asthma body of knowledge
Atherosclerosis Vaccine Development - Chimeric enzyme vaccine attenuated atherosclerosis in rabbit model
Autoimmune Disease - MRCP imaging of the MPD helps diagnose pancreatitis with autoimmune phenomenon, but a negative result does not preclude such diagnosis
Cancer Vaccines - Reports describe recent advances in cancer vaccines research
Bacteriology - S. aureus PNAG production needed for virulence in murine models of systemic infection
Biomarkers - Apolipoprotein D downregulated during malignant transformation of neurofibromas
Biomedical Engineering - Streptomyces subtilisin inhibitor SCO4010 appears to be a pseudogene
Biomedical Engineering - Cryopreserved skin substitutes release cytokines essential for wound healing
Biomedical Engineering - Infrared spectroscopy and [13C]Tyr labeling reveal structural changes in cytochrome bo
Biomedical Engineering - Review examines enzyme action on immobilized substrates
Diabetes Therapy - Recent findings in diabetes therapy described
Botulinum Neurotoxin - Antibody response to receptor binding domain of botulinum serotypes examined
Breast Cancer - Low-density microarrays suitable for characterization of tumor cell lines
Cancer Research - Stanford study shows dual role of protein menin in cancer growth
Cancer Therapy - Butyrate regulates sphingomyelin in colon and liver cancer cells
Cancer Therapy - Findings advance knowledge in cancer therapy research
Cancer Therapy - Four diterpenoid inhibitors of Cdc25B phosphatase extracted from marine anemone
Diabetes Therapy - Recent studies add new data to diabetes therapy research
Cancer Therapy - New strategies for treatment of lymphoma described
Cancer Therapy - Preliminary results reported from randomized phase II trial of Avastin and Tarceva in kidney cancer
Cancer Therapy - Src inhibition may be feasible for treating pancreatic cancer
Cancer Therapy - Target suppression and antitumor activity of MEK inhibitor CI-1040 demonstrated
Cancer Therapy - VEGF conjugate guides boronated dendrimers to tumor vessels
Infections - Research in infections provides new insights
Cancer Vaccine Development - Epitopes recognized by antibodies specific for tumor antigen NY-ESO-1 identified
Cancer Vaccine Development - Immunotherapy of glioblastoma multiforme stimulates CTL reaction
Cancer Vaccines - New findings in cancer vaccines described
Cardiology - Hepatocyte growth factor gene therapy blunts vascular remodeling in hypertrophic hearts
Leukemia - Researchers' work adds to leukemia body of knowledge
Cardiomyopathy - Arrhythmogenic right ventricular cardiomyopathies have common pathway
Cervical Cancer - Genetic patterns signal angiogenesis and tumor invasion in cervical carcinomas
Chemotherapy - Bamet-UD2 overcomes resistance to cisplatin
Chemotherapy - Irinotecan plus temozolomide was well tolerated in malignant glioma patients
Chemotherapy - Platinum compound inhibits Stat3 signaling and induces cell cycle arrest
Childhood Obesity - Findings describe new data in childhood obesity research
Neurology - Recent findings in neurology provide new insights
Childhood Obesity - Weight loss improved the cardiovascular risk profile in obese children
Choriocarcinoma - Adrenomedullin enhances invasion by trophoblast cell lines
Chronic Heart Failure - Flow-mediated vasodilation predicts outcome in patients with chronic heart failure
Clinical Trials - DNA 'prime-boost' vaccine technology enters phase 2 clinical trial for HIV
Collaborations - Alliance focuses on protein structures, to prioritize proteins as drug targets
Collaborations - DirectDesign Discovery collaboration inked with KAI Pharmaceuticals
Neuroscience - Reports add new data to neuroscience research
Colon Cancer - Recent findings in colon cancer provide new insights
Colorectal Cancer - Researchers detail new studies and findings in the area of colorectal cancer
Coronary Artery Disease - L-Arginine bolsters angiogenic response in hypercholesterolemia models
DNA Research - A467T mutation causes lower polymerase activity and loss of accessory subunit interaction
DNA Research - Mycobacteria Ag85B elicits effective CTL responses
Dermatology - Plasmin-induced smooth muscle cell proliferation requires extracellular activation of EGF
Neuroscience - Research add new data to neuroscience body of knowledge
Developmental Biology - Slit-like 2 regulates zebrafish vascular and nervous system morphogenesis
Diabetes Pathogenesis - SOCS7 deletion enhances insulin action and increases islet size
Diabetes Therapy - Findings advance knowledge in diabetes therapy research
Diabetes Vaccine Development - Glutamic acid decarboxylase peptide expands diabetogenic T cell clone
Neuroscience - Researchers provide details of new studies and findings in the area of neuroscience
Diabetic Nephropathy - Meprin-alpha appears to play a role in chronic diabetic nephropathy
Diagnostics - Exclusive testing rights for SHOX gene testing expanded to include EU
Diagnostics - Features of diffuse epidermal and periadnexal squamous cell carcinoma described
Diagnostics - Nonprion biomarkers proposed for diagnosis of TSE in live subjects
Diagnostics - Real-time telomerase activity measurements may be useful cancer detection method
Diagnostics - Research in diagnostics provides new insights
Neuroscience - Researchers report details of new studies and findings in the area of neuroscience
Disease Associations - Elevated brain natriuretic peptide is diagnostic of chronic obstructive pulmonary disease
Drug Abuse - Detection of designer 4-MTA in human urine was successful using GC-MS
Drug Development - Acetohydroxyacid synthase inhibitor active against Mycobacterium tuberculosis
Drug Development - Highly immunogenic hepatitis C virus peptides may produce new therapy
Drug Development - Inhibition of matriptase prevents invasive growth of prostate and colon cancers
Drug Development - Novel antimutagenic factors derived from mushroom Agrocybe cylindracea
Neuroscience - Studies add new findings to neuroscience body of knowledge
Drug Development - Progress is reported toward acetate supplementation therapy for Canavan disease
Drug Development - Screen couples Cyt P450 online bioaffinity detection with gradient reversed-phase HPLC
Drug Research - Plasma homocysteine is not increased by the chronic administration of nandrolone
Drug Resistance - New findings in the area of drug resistance described
Dyslexia - The novel discovery of "DCDC2" gene is associated with dyslexia
Ebola Virus - Complete genome of Ebola virus causing outbreak in Uganda released
Proteomics - Recent findings in proteomics provide new insights
Endocrinology - Recent findings in endocrinology provide new insights
Enzymology - Ser/Thr kinase is expressed nonubiquitously in mice and men
Escherichia Coli - Non-O157 Shiga toxin-producing E. coli infections in U.S. reviewed
Finance - Proteomics-focused diagnostics company reports 14% increase in revenue
Gastric Cancer Vaccine - Ig superfamily 11 (IGSF11) is target for gastrointestinal and liver cancer
Gastroenterology - Fluorescent protein knock-in mouse model facilitates study of KIT-positive cells
Proteomics - Research in proteomics provides new insights
Genetics & Genomics - A protein in St. John's wort is found to suppress HIV-1 gene expression
Genetics & Genomics - BRCA1 and BRCA2 marked as ovarian cancer susceptibility genes
Genetics & Genomics - Increased genomic instability leads to higher cancer incidence in elderly
Genetics & Genomics - Scientists examine the genetics of the first 15 minutes of life
Genomic Phenotyping - Colonic phenotype occurs rarely in gastric carcinogenesis
Genotoxicity - Handling of antineoplastic drugs associated with genotoxic risks in oncology nurses
Proteomics - Researchers report details of new studies and findings in the area of proteomics
Glioblastoma Multiforme - Novel treatment target for deadly brain tumors is identified
HIV/AIDS Pathogenesis - Cul5-E3 ligase is a common pathway hijacked by HIV-1 Vif to defeat h-A3F and h-A3G
HIV/AIDS Vaccine Development - CD8+ lymphocytes do not protect against acute SIV superinfection
HIV/AIDS Vaccine Development - Research collaboration formed to develop topical delivery of therapeutic DNA vaccines
HIV/AIDS-Related Atherosclerosis - HIV-1 Tat induces VCAM-1 expression in pulmonary artery endothelial cells
Hepatitis B Virus - Membrane heparan sulfate interactions facilitate hepatitis B virus-induced cytokine production
Vector Development - Reports describe recent advances in vector development research
Hepatitis B Virus - Residues modulate hepatitis B virus X protein binding
Hepatitis C Therapy - Lactoferrin has no effect on the response of chronic hepatitis C to standard therapy
Hepatitis C Vaccine Development - Epitope characterization paves the way for hepatitis C peptide-based vaccines
Hepatocellular Cancer - Different immunohistochemical features detected between scirrhous and normal HCC
Hookworm Vaccine Development - Hookworm heme-binding glutathione transferase has vaccine potential
Hormones - Aldosterone increases osteopontin gene expression in rat endothelial cells
Virology - Researchers publish new studies and findings in the area of virology
Hormones - Cardiopulmonary bypass and surgical intervention affects natriuretic hormone system in children
Hormones - Thyroid hormone modulates renin and ANG II receptor expression in fetal sheep
Hypertension - Calcitonin gene-related peptide functions in hypertension
Infections - Findings in infections provide new insights
Information Technology - License agreement with Ensemble Discovery signed for molecular modeling software
Insulin Resistance - Researchers publish new studies and findings in the area of insulin resistance
Insulin Resistance - Skeletal muscle insulin resistance appears to be of genetic origin
Insulin Resistance - Urinary myo-/chiro-inositol ratios are elevated in diabetes patients
Ischemia - Uncoupling proteins augment tolerance to cardiac ischemia
Islet Transplantation - Islet-like cell clusters develop after pancreas transplantation
Islet Transplantation - Recent studies add new data to islet transplantation research
Leptin Studies - Metabolic regulation by leptin has implications for glucose homeostasis
Leukemia - Reports describe recent advances in leukemia research
Liver Cancer Vaccine Development - Autoantibodies against tumor-associated antigens in liver cancer identified
Lung Transplantation - Glutathione improves the function of porcine pulmonary grafts
Malaria Vaccine - Polymorphisms in malaria T cell epitopes not selected by immune pressure
Malaria Vaccine Development - Changes in host cell tropism limits efficacy of malaria vaccine
Medical Devices - SELDI-TOF mass spectrometry proposed for biomarker discovery and serum proteomic study
Medulloblastoma - New brain tumor model is developed
Meningitis Vaccine Development - Anti-idiotypic antibody is candidate for meningitis vaccine
Meningitis Vaccine Development - Meningococci from invasive meningococcal disease cases in Canada characterized
Molecular Biology - Disease progression accelerates in response to hypoxia
Molecular Biology - Researchers find that a baby's genes affect the mother's cholesterol levels
Mosquito-Borne Disease - Reports describe recent advances in mosquito-borne disease research
Neurology - New findings in the area of neurology detailed
Neuropeptides - Additional class of neuropeptide Y receptor sites exists in rat brain
Neuroscience - Recent findings illuminate research in neuroscience
Obesity Genomics and Genetics - Mature adipocytes play active role in obesity-related inflammation
Obesity Pathogenesis - Double leptin and melanocortin-4 receptor gene mutations reduce leptin's effects
Obesity Pathogenesis - Effect of high-fat diet on amine oxidase activity in adipose tissue examined
Obesity Pathogenesis - Resistin and ghrelin increase adhesion molecule expression on vascular endothelial cells
Obesity and Diabetes - Differential expression of proteins in pancreas of diabetic mice examined
Obesity and Diabetes - Soluble VAP-1/SSAO release stimulated by isoproterenol and low TNF-alpha levels
Obesity and Diabetes - Weight loss decreases insulin resistance index in obese children
Obstetrics - Angiogenic balance may be essential for evading preeclampsia
Oncology - Cyclin A1 mediates vascular endothelial growth factor signals in prostate cancer
Oncology - Endoglin and vascular endothelial growth factor mark esophageal adenocarcinoma angiogenesis
Oncology - Hepatitis B virus X protein may permit cancer formation by limiting DNA repair
Oncology - Recent findings in oncology provide new insights
Oncology - Receptor engagement drives tumor neovascularization
Ophthalmology - Cytochrome P450 antagonists may prevent corneal neovascularization
Ophthalmology - Researchers' data advance ophthalmology research
Patents - Patents for rheumatoid arthritis compound granted by European Patent Office
Patents - U.S. patent awarded for UCOE gene expression technology
Peptides - Intermedin may function as a cardiovascular active peptide
Physiology - C-terminal amino acids of SUR2A and SUR2B function in cardiovascular ATP-sensitive K+ channels
Physiology - Carbonyl reductase is involved in pig heart superoxide
Physiology - Recent findings in physiology provide new insights
Physiology - Synergistic interactions between Ca2+ entries occur in normal and failing rat heart
Prognostics - Cystatin C expression used as prognostic indicator of gliomas
Prognostics - Dysadherin expression used to prognosticate non-small cell lung cancer
Proteomics - Dictyostelium discoideum requires PhLP1 for Gbeta-gamma dimer formation
Proteomics - Findings in proteomics provide new insights
Proteomics - GTPase Sar1p initiates membrane curvature and completes fission of COPII vesicle
Proteomics - Genedata comarkets solution for high-throughput protein-gel processing
Proteomics - Novel method identifies potential biomarkers in human plasma proteome rapidly
Proteomics - Precision automated platform for baculovirus production launched
Proteomics - Pregnancy-associated plasma protein-A modulates stem cell matrix mineralization and angiogenesis
Proteomics - Protein measurement company receives $500,000 SBIR grant from U.S. National Science Foundation
Proteomics - Structure of enzyme-product complex reveals active site mechanism
Proteomics - UCP3 protects aconitase against inactivation, skeletal muscle model indicates
RNA Research - Phase 1 trial data on RNA molecule for age-related macular degeneration updated
Radiation Therapy - Proteasome inhibition improved fractionated radiation treatment
SARS - Reports advance knowledge in SARS research
Smallpox Vaccines - Reports describe recent advances in smallpox vaccines research
Stem Cell Research - Chromatin-related proteins maintain the unique properties of pluripotent ESCs
Stem Cell Research - Lineage trees for cells: scientists develop a new analytical method
Streptococcal Vaccine - Antibodies to iron uptake ABC transporter lipoproteins promote phagocytosis of Streptococcus
Stroke - Circulating beta amyloid protein is elevated in patients with acute ischemic stroke
Tissue Engineering - Microstructured titanium scaffolds direct the behavior of MC3T3-E1 preosteoblasts
Vaccine Adjuvant - Salmonella flagellin component potentiates immune responses
Vaccine Development - Recombinant antibody libraries aid vaccine research
Vasodilation - Circulating elastin peptide levels decrease in humans with sepsis
Vector Development - Findings describe new data in vector development research
Virology - Findings in virology provide new insights
Virology - Hepatitis B virus pseudotypes elucidate early infection activity
Virology - Herpes simplex virus glycoprotein B blocks virus entry
Virology - Liver enzyme flares require scrutiny in HIV-HCV coinfected patients beginning therapy
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