Proteomics

P-gp expression, but not BCRP, upregulated in early pregnancy to protect fetus

Published in Proteomics Weekly, November 14th, 2005

Placental P-glycoprotein expression, but not breast cancer resistance protein, may be upregulated in early pregnancy to protect the fetus from xenobiotic toxicity.

"Placental efflux transporters such as P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP) protect the developing fetus from exposure to potentially toxic xenobiotics. However, little is known about the expression of these transporters in human placentae of different gestational ages," scientists writing in the American Journal of Physiology - Regulatory Integrative and Comparative Physiology report.

"Therefore," proposed A.A. Mathias and colleagues, University of...

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Source: Proteomics Weekly (2005-11-14)

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