Proteomics Weekly
Susan Hasty, Publisher
Table of Contents . . . December 19th, 2005
Non-Subscriber - Summaries OnlyRelated Areas: Other Issues in Proteomics Weekly | Other Publications
Diabetes Pathogenesis - Gap junction protein expression and innervation remodeling are linked to bladder dysfunction
Diagnostics - Heat-shock protein 65 gene analysis differentiates Mycobacterium species
Hepatitis C Pathology - Researchers provide new insights into protein synthesis and hepatitis C infections
Prostate Cancer - Scientists identify molecule that may contribute to prostate tumor formation growth
Tuberculosis Pathogenesis - Protein coded by Rv1747 gene required for normal virulent MTB infection
Adenovirus Vectors - Peptide-presenting libraries allow choice of peptide ligands for viral vector retargeting
Adipose Tissue - Nnat increases CREB phosphorylation and enhances adipogenic differentiation in rat model
Alzheimer Disease - CD40 ligation in microglia perturbs genes associated with amyloid protein
Alzheimer Disease - New findings in Alzheimer disease described
Alzheimer Disease Vaccine - MPL with trehalose dicorynomycolate is effective vaccine adjuvant
Anthrax Vaccines Development - New data illuminates research in anthrax vaccines development
Apoptosis - Researchers describe findings in apoptosis studies
Antibacterial Agents - Porcine peptidoglycan recognition proteins are involved in antimicrobial peptide expression
Apoptosis - Gleditsia sinensis fruit extract induced apoptosis in human carcinoma cells
Apoptosis - Data advance knowledge in apoptosis research
Apoptosis - Increased antiapoptotic protein expression increases chemical susceptibility of skin tumors
Apoptosis - The BAD protein integrates survival signaling in tumor cells
Diabetes Pathogenesis - Recent findings in diabetes pathogenesis provide new insights
Arteriogenesis - Vector encoding sphingosine kinase boosts revascularization in rabbit ischemic limbs
Arthritis Pathogenesis - Autoimmune arthritis requires T cell response to multiple epitopes
Aspergillosis - IFN-gamma overexpression promotes Aspergillus clearance in pulmonary aspergillosis
Atherosclerosis - Expression of scavenger receptor CD may accelerate atherosclerosis progress in diabetics
Atherosclerosis - Insulin regulates p70S6k and 4E-BP1 in HUVEC/HVSMC cells and promotes atherosclerosis
Atherosclerosis - MMP-9 microsatellite polymorphism is linked to carotid atherosclerotic plaques
Diabetes Pathogenesis - Researchers publish new studies and findings in the area of diabetes pathogenesis
Bacteriology - Highly specific new bacteria were detected in women with bacterial vaginosis
Biotechnology - Silicon based signal generation and detection system allows monitoring of DNA hybridization
Bladder Cancer - Loss of CAR expression associated with aggressive disease
Breast Cancer - ADAM 12-mediated focal adhesion formation is differently regulated by integrins
Breast Cancer - C-MYC Asn-11-Ser polymorphism associated with increased risk for familial breast cancer
Breast Cancer - Overexpression of CC3/TIP30 is associated with HER-2/neu status in breast cancer
Diagnostics - Studies advance knowledge in diagnostics research
Breast Cancer Vaccine - Overexpression of protein fragment sensitizes MDA-MB-231 breast tumor cells to radiation
Bunyamwera Virus - Role of Bunyamwera virus glycoproteins in virus infectivity is examined
Business & Finance - Protein-focused biotech company executes $2.5 million debt financing agreement
Cancer Gene Therapy - Clusterin is a therapeutic target for radiation sensitization in lung cancer
Cancer Gene Therapy - Transduced peripheral blood lymphocytes recognize fresh human tumor
Cancer Metastasis - Insulin-like growth factors stimulate lymphangiogenesis
Neuroscience - Researchers describe findings in neuroscience studies
Cancer Research - CAPE sensitizes CT26 colorectal adenocarcinoma to IR, does not affect marrow radioresponse
Cancer Research - Serum levels of soluble ICAM-1 and VCAM-1 can be used to predict preclinical cancer
Cancer Research - Vitamin E pre-treatment reduces the degree of oxidative stress induced by NDEA
Cancer Research - p53 Molecular bridge distruption may produce clumps, suggesting link to adrenocortical carcinoma
Cancer Therapy - Analysis of ABCC1 clarifies leukotriene C4 binding sites
Cancer Therapy - Breast tumor cell growth attenuated by conjugated linoleic acid
Oncology - Reports add new data to oncology research
Cancer Therapy - Chromosomal deletions in B-cell lymphoma identify candidate tumor suppressor genes
Cancer Therapy - Continuous exposure to low-dose cisplatin induced apoptosis in rat hepatoma AH-109A cells
Cancer Therapy - Downmodulation of E1A protein expression used to aid design of cancer-selective adenoviruses
Cancer Therapy - Extracellular matrix protein fragments offer new avenues for stopping tumor angiogenesis
Cancer Therapy - Genasense reported to enhance preclinical activity of Tarceva with intermittent dosing schedule
Cancer Therapy - IL-17 enhances angiogenic activity and growth of non-small cell lung cancer
Oncology - Researchers publish new studies and findings in the area of oncology
Cancer Therapy - Irradiation down-regulates SMT3A gene expression in nevoid basal cell carcinoma
Cancer Therapy - PS-341 did not improve condition in patients with metastatic pancreatic adenocarcinoma
Cancer Therapy - Studies add new findings to cancer therapy body of knowledge
Cancer Therapy - Targeted blockade of p38 alpha MAPK helps hypericin-based photodynamic therapy fight cancer
Cancer Therapy - Telomerase antagonists inhibit tumor growth and increase hepatoma chemosensitivity
Proteomics - Recent findings illuminate research in proteomics
Cancer Vaccine - Epitope from cancer testis antigen was presented by dendritic cells to CD4+ T cells
Cancer Vaccine - Mechanism of DNA topoisomerase poisoning was investigated
Carcinogenesis - A cellular model recreates the transformation of oral-esophageal cancer cells
Carcinogenesis - Hormesis and dose-response-mediated mechanisms in carcinogenesis discussed
Cardiology - Cord blood stem cells and gene therapy combine to spur angiogenesis after myocardial infarction
Cardiomyopathy - Recent findings illuminate research in cardiomyopathy
Proteomics - Recent studies add new data to proteomics research
Cardiovascular Disease - Periodonitis patient's plasma lipoprotein profile may be link with cardiovascular disease
Cell Biology - Interferring with cells' hypoxia mechanisms may enhance solid tumor treatment efficacy
Cell Biology - Scientists study how hatchways allow nutrients to enter cells
Chemotherapy - Imatinib and hydroxyurea used to treat progressive glioblastoma multiforme
Clinical Trials - Positive final results reported from phase II study of diabetic nephropathy therapy
Clinical Trials - Updated trial data on therapy for advanced ovarian cancer is promising
Proteomics - Researchers provide details of new studies and findings in the area of proteomics
Collaborations - Biotechnology company and Covalys collaborate on novel SNAP-tag protein products
Collaborations - German companies collaborate on monoclonal antibodies to human GPCR cancer targets
Complementary & Alternative Medicine - Glycolipids fraction from spinach displayed anticancer activity
DNA Research - Modified sam1 gene obtained with rare codons through the use of extension PCR
DNA Research - Quercetin inhibition of iNOS gene expression is mediated by the inhibition of microglial factors
DNA Research - Simple cationic peptide motif allows delivery of antisense peptide nucleic acid
Virology - Studies add new findings to virology body of knowledge
DNA Research - Telomerase-based approach detects natural cell-mediated cytotoxic activity
DNA Vaccine - Oligodeoxynucleotide enhances efficacy of DNA vaccine and treats autoimmune disease
Dendritic Cell Vaccine - Melanoma cell necrosis facilitates transfer of antigens onto dendritic cells
Dermatology - Hairless gene compound nonsense mutations are associated with atrichia with papular lesions
Developmental Biology - A Drosophila MSL complex homolog is responsible for much histone H4 acetylation
Developmental Biology - Amyloid beta alters Akt activity and affects mitochondrial function
Developmental Biology - Induction of secretive bone morphogenetic protein 2 could promote osteogenetic differentiation
Developmental Biology - MAPK inhibition induces parthenogenetic activation during oocyte maturation
Developmental Biology - Neural-crest cell differentiation is modulated by regulation of LEF1 protein stability
Developmental Biology - Ortholog of the mammalian CBP/p300 gene increases histone acetyltransferase activity
Developmental Biology - Trophoblast amino acid transport is inhibited by interleukin-1 beta
Developmental Biology - Werner syndrome is associated with gene misregulation
Diabetes Complications - Vasculopathy in diabetic retinopathy forms apart from neuronal and glial changes
Diabetes Control - Glucagon-like peptide 1 signaling pathway is type 2 diabetes treatment target
Diabetes Pathogenesis - Diabetes alters hepatic 3-hydroxy-3-methylglutaryl-CoA reductase promoter occupancy
Diabetes Pathogenesis - MMP-2 may be marker of microangiopathy in youth with type 1 diabetes mellitus
Diabetes Pathogenesis - Pancreatic acinar cells can transdifferentiate into insulin-secreting cells
Diabetes Pathogenesis - Recent findings illuminate research in diabetes pathogenesis
Diabetes Therapy - Recent findings in diabetes therapy described
Diagnostics - Nucleic acids company enters distribution agreement for preanalytical consumables and technologies
Diagnostics - Positive nestin-immunoreaction used to diagnose clear cell tumors in adrenal glands
Diagnostics - Reports add new data to diagnostics research
Disease Associations - Postprandial lipid metabolism is a link between adiponectin and liver disease
Drug Delivery - Molecular weight of PEG emulsifier is key determinant of PLGA microsphere drug release
Drug Development - Compound shown effective in preventing plaque that leads to development of Alzheimer disease
Drug Development - Pharma company to license novel drug target for HIV treatment
Drug Development - Sartorius BBI Systems bioreactors picked for Oklahoma City biopharmaceutical manufacturing facility
Electrophoresis - Electrospray interfacing of polymer microfluidics to MALDI-MS achieved
Endocrinology - Triamcinolone acetonide renders VEGF mRNA unstable in Muller cells stimulated with cobalt
Environmental Health - Benzene increases protein-bound 3-nitrotyrosine in bone marrow of B6C3F1 mice
Environmental Health - Somatic and germ cell DNA damage in acrylamide-treated mice depends upon CYP2E1 activity
Foot-&-Mouth Disease Vaccine - New mucosal vaccine against foot-and-mouth disease virus protects mice and swine
Gastric Cancer - Cyclooxygenase-2 is an independent prognostic factor in gastric cancer
Gastritis - VEGF and angiogenesis stimulate Helicobacter pylori-related gastritis
Gastroenteritis Vaccine - Shiga toxin subunit::rotavirus fusion protein protects against gastroenteritis
Gastroenterology - Lamina propria dendritic cells play large role in gastrointestinal physiology
Gene Research - Administration of caffeine or green tea affected mutation profile in murine p53 gene
Gene Research - RNA nuclear retention allows the regulation of gene expression
Genetics & Genomics - Development genes evolve new functions
Genetics & Genomics - Differential steroidogenic gene expression occurs in the fetal adrenal gland
Genetics & Genomics - Embryonic sensitivity to heat-stress is mediated by gene expression
HIV/AIDS Diagnostics - Results demonstrate importance of reagent selection for monitoring of HIV responses
HIV/AIDS Research - HIV/AIDS research shows new drugs offer alternatives for individualized care
HIV/AIDS Research - Kaletra combination therapy shown to maintain undetectable viral load in HIV patients
HIV/AIDS Research - New European HIV treatment guidelines recommend boosted Invirase as first choice protease inhibitor
HIV/AIDS Therapy - Antiretroviral therapy interruption during chronic HIV-1 infection is not beneficial
HIV/AIDS Therapy - U.S. FDA approves updated labeling for LEXIVA
HIV/AIDS Vaccine Development - Envelope vaccines derived from South African subtype C HIV-1 TV1 strain have been evaluated
HIV/AIDS Vaccine Development - Semliki Forest virus particles efficiently expand HIV-1-specific T cell responses
HIV/AIDS-Associated Pulmonary Hypertension - Secreted HIV gp120 proteins induce lung endothelial cell injury
Head & Neck Cancer - Coexpressed molecular markers identify progression risk in patients with oral cancer
Hematology - Erythropoietin multiplies the proliferative and adhesive properties of endothelial progenitor cells
Hemochromatosis - Dose-response effects of ectopic agouti protein on iron overload were examined
Hepatitis B Therapy - Interferon-alpha and lamivudine combination yields higher therapeutic efficacy
Hepatitis B Virus - Hepatitis B virus DNA in blood donors is a possible indicator of active infection
Hepatitis C Therapy - Recent findings in hepatitis C therapy provide new insights
Hepatitis C Virus - HCV monoclonal antibodies against E2 glycoprotein possess neutralizing activity
Hepatitis C Virus - HCV mutations confer cross-resistance against Ser protease inhibitors
Hepatitis C Virus - Signal peptide peptidase promotes the formation of HCV non-enveloped particles
Hepatitis C Virus - Transient-replication assay allows quantitation of hepatitis C viral RNA replication
Heptatitis C Virus - Alpha interferon inhibits translation mediated by hepatitis C virus genotypes
Herpes Simplex Virus - Protein kinase activity of herpes simplex virus is not needed for optimal UL41 and ICP0 expression
Immunology - TRAF6 binding domain is required for cytokine production in lung fibroblasts
Immunotherapy - Anti-cyclic citrullinated peptide antibodies are present in autoimmune hepatitis
Infectious Bronchitis Virus - Trafficking signals in bronchitis virus spike protein are needed for virus infection
Infectious Diseases - Giardia lamblia surface protein cytotoxicity is enzymatically controlled
Influenza Vaccine - Conserved influenza A epitopes in humans and transgenic mice are described
Information Technology - Bioinformatics company launches Internet accessible cell signaling proteomics database
Leukodystrophy - Data advance knowledge in leukodystrophy research
Lung Cancer - Arginase I in myeloid suppressor cells is induced by COX-2
Malaria Vaccines - New findings in the area of malaria vaccines described
Melanoma - Altered E prostanoid (EP) receptor expression implicated in development of melanoma
Melanoma - Expression of activated Akt and PTEN in malignant melanomas did not relate to clinical outcome
Meningitis Pathogenesis - Salivary IgA plays role in host defense to Neisseria meningitidis
Mergers & Acquisitions - Biotech company announces intention to merge with Thuris Corporation
Mergers & Acquisitions - Developer of anticancer drugs announces transaction to become private company
Mergers & Acquisitions - Swedish biotech acquires Nurel Therapeutics
Neurogenesis - TNF-alpha antibody infusion impairs survival of stroke-generated neuroblasts
Neurogenesis - Wnt signaling regulates adult hippocampal neurogenesis
Neuropeptides - Researchers report details of new studies and findings in the area of neuropeptides
Neuroscience - Drug-development company announces receipt of extended funding from Wyeth
Neuroscience - Increased processing of amyloid precursor and precursor-like proteins is shown
Neuroscience - Recent findings illuminate research in neuroscience
Neuroscience - Research defines role of synaptotrophin proteins in maintaining healthy synapses
Obesity Pathogenesis - Adiponectin levels depend on adipocyte differentiation and high molar mass serum components
Obesity Research - Fatty acid metabolism in hypothalamus and melanocortin system may provide obesity targets
Oncology - New data illuminates research in oncology
Oncology - VEGF may be a prognostic indicator in head and neck squamous cell carcinoma
Ophthalmology - Estrogen decline may cause older women to form degenerative eye disease
Ophthalmology - Mutant fibulin proteins trigger signals leading to choroidal neovascularization
Osteogenesis - Protein synergy modulates angiogenesis in healing and developing bones
Osteogenesis - VEGF gene-activated matrix accelerates bone healing
Pancreatic Cancer - Elastase modulates endostatin production in pancreatic cells
Pancreatic Cancer Therapy - Lupeol induced apoptotic death of human pancreatic adenocarcinoma cells
Parkinson Disease - Central nervous system receptor may have function in Parkinson neuron degeneration
Personnel - Protein therapeutics company recruits three key management team additions
Pertussis Vaccine - Antibodies directed against pentasaccharide-tetanus toxoid conjugate exhibit anti-endotoxin activity
Physiology - Findings describe new data in physiology research
Pneumococcal Vaccine - ELISA is developed to detect invasive pneumococcal disease in children
Pneumococcal Vaccine - Microbes may modulate antibody response to glucuronoxylomannan in AIDS
Prions - New findings in the area of prions described
Product Licensing - Merck & Co. licenses automated scientific text processing tool
Prognostics - High p53 expression associated with poorer prognosis in primary melanoma
Prognostics - MCM4 expression prognosticated esophageal cancer
Protein Production - Medicago truncatula is a promising protein production system
Proteomics - Citrullination of fibronectin fosters rheumatoid arthritis pathogenesis
Proteomics - Macrophage-selective marker displays specificity in adipocytes
Proteomics - New data illuminates research in proteomics
Proteomics - Pseudorabies virus UL17 protein is characterized
Proteomics - Thombospondin may be linked to angiogenic suppression in ischemic limbs
Pseudomonas - Fusion protein-truncated Pseudomonas exotoxin A in E. coli is characterized
Psoriasis - Danish researcher receives grant for psoriasis research
Rotavirus Vaccine - Antibody responses against rotavirus protein after vaccination or infection have been evaluated
Rotavirus Vaccine - Method for triple-layered rotavirus virus-like particle production is developed
Skin Cancer Vaccine - Melanoma progression occurs despite high levels of CD8+ T cells
Smallpox Vaccine - Combinations of antibodies to vaccinia virus proteins protect against respiratory challenge
Stem Cell Research - Endothelial progenitor cells respond to PAR-1 with concentration-dependent angiogenesis
Stem Cell Research - Study provides insight into complexity of Notch signaling in mammalian CNS development
Stroke - Cellular factor boosts angiogenesis after focal cerebral ischemia
Thermogenesis - Low oxygen levels do not increase cold-induced VEGF in brown adipose tissue
Thrombosis - Researchers describe findings in thrombosis studies
Tuberculosis Vaccine - Recombinant antigens of M. tuberculosis for serodiagnosis were purified
Vaccine Delivery - Histidylated lipid-modified Sendai viral envelopes enhance membrane fusion
Vaccine Efficacy - Response to antigen contributes more to immunological memory than cell number increases
Vector Development - Hereditary persistence of fetal hemoglobin 2 enhancer increases onco-retrovirus vector expression
Virology - Proviral DNA viral load may be diagnostic for myelopathy/tropical spastic paraparesis
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