Mast Cells

Tryptase- and chymase-related gene clusters identified in human mast cells

Published in Proteomics Weekly, March 20th, 2006

Recent research from Denmark has reported on the identification of tryptase- and chymase-related gene clusters in human mast cells (MCs).

"Tryptase and chymase are the two major granular proteases present in human MC. We used oligonucleotide microarray to measure the levels of approximately 22 000 transcripts in cord blood-derived MCs at 4 weeks, 8 weeks, 12 weeks and 18 weeks in culture," wrote C. Dahl and colleagues, Aarhus University Hospital.

"Tryptase (TPSB2) was expressed at the highest level among all transcripts and its expression level reached a plateau at 8 weeks. On the other hand, the expression level of chymase (CMAI) doubled every 4-6...

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Source: Proteomics Weekly (2006-03-20)

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