Breast Cancer

HER-2/neu expression used to prognosticate primary breast cancer

Published in Proteomics Weekly, March 20th, 2006

HER-2/neu expression could be used to predict sentinel lymph node (SLN) metastasis in primary breast cancer.

According to a study from the United States, "Amplification of the protein product of the HER-2/neu oncogene in primary breast cancer specimens is associated with an adverse prognosis. We hypothesized that overexpression of HER-2/neu would predict metastases to the SLNs. A retrospective review of a prospective nonrandomized evaluation of 1055 clinically node-negative breast cancer patients undergoing 1063 SLN biopsies was performed."

"HER-2/neu analysis was performed by immunohistochemistry and, in selected cases, by fluorescence in situ...

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Source: Proteomics Weekly (2006-03-20)

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