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Proteomics

Peptide microarray devised for chromogranin A antigenic site study

Published in Proteomics Weekly, March 20th, 2006

A novel peptide microarray design may facilitate the characterization of chromogranin A antigenic sites.

"Microarraying peptides is a powerful proteomics technique for studying molecular recognition events," scientists in Italy explained. "Since peptides have small molecular mass, they are not easily accessible when adsorbed onto solid supports."

"Moreover, peptides can lack a well-defined 3-dimensional structure, and therefore a correct orientation is essential to promote the interaction with their target," noted M. Chiari and colleagues working at the Istituto di Chimica del Riconoscimento Molecolare in Milan.

In a recent study,...

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