Colorectal Adenocarcinomas
Colorectal carcinoma tumor-associated stroma has a metabolic survival role
Published in Proteomics Weekly, March 20th, 2006
"Understanding tumor metabolism is important for the development of anticancer therapies. Immunohistochemical evaluation of colorectal adenocarcinomas showed that cancer cells share common enzyme/transporter activities suggestive of an anaerobic metabolism [high lactate dehydrogenase 5 (LDH5)/hypoxia-inducible factor alphas (HIF alphas)] with high ability for glucose absorption and lactate extrusion [high glucose transporter 1 (GLUT1)/monocarboxylate transporter (MCT1)]," researchers in Greece reported.
"The tumor-associated fibroblasts expressed proteins...
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Source: Proteomics Weekly (2006-03-20)
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