Proteomics Weekly

Cardiomyocytes - TAK-1-binding protein modulates localization of p38 MAP kinase and downstream signaling

Hepatitis B Virus - Hepatitis B surface and core antigen coinoculation promotes HIV-1 immune response

Proteomics - In Marfan syndrome, matrix metalloproteinase-1 may be dysregulated by fibrillin fragmentation

Proteomics - Proteome and transcriptome markers of autoimmune diabetes risk identified

Stem Cell Research - La protein required for development and establishment of embryonic stem cells

Acute Myeloid Leukemia - Acute myeloid leukemia patients with KIT-D816 mutations linked to poor prognosis

Acute Myeloid Leukemia - Poor prognosis in pediatric acute myeloid leukemia linked to KIT mutations

Adverse Drug Reaction - Adverse effects are associated with bone morphogenetic protein-2 use

Allergy & Immunology - Lymphocytes and monocyte CD4 differ in structure and protein association

Allergy & Immunology - Mite allergen proform glycosylation decelerates the speed of maturation

Ampullary Cancer - Loss of expression of E-cadherin and beta-catenin linked to poor prognosis in ampullary cancer

Angiology - Myosin phosphatase isoform switching may determine responses to NO/cGMP signaling

Angiology - Protein tyrosine phosphatase inhibition improves vascular endothelial dysfunction

Angiology - Researchers describe findings in angiology studies

Apoptosis - Co-expression of metallothionein and p53 implicated in tumor cell apoptosis

Apoptosis - Neuronal apoptosis involves Bid cleavage and translocation to mitochondria

Apoptosis - Researchers' work adds to apoptosis body of knowledge

Apoptosis - p73 overexpression enhanced cisplatin-induced apoptosis in HeLa cells

Asthma - Plasma protein pattern exhibited in pregnant asthmatics may offer prognostic significance

Atherosclerosis - RAGE modulates vascular inflammation and atherosclerosis in a murine type 2 diabetes model

Bacteriology - New findings in the area of bacteriology detailed

Breast Cancer - Breast cancer metastasis and patient outcomes correlate with VEGF-C

Breast Cancer - Breast cancer prognosis and survival associate with S100A4 and osteopontin

Breast Cancer - Breast cancer resistance protein and p-glycoprotein modulated by corticosteroids

Breast Cancer - New data illuminates research in breast cancer

Breast Cancer - Researchers describe findings in breast cancer studies

Breast Cancer - Studies advance knowledge in breast cancer research

Business Update - CytoCore's InPath System upgrades Pap test, offers new drug delivery system

Business Update - CytoGenix enters into a supply agreement with GE Healthcare for DNA production reagents

Business Update - GlaxoSmithKline uses Fluidigm technology to solve structure of human cytochrome P450 2D6

Cancer Gene Therapy - Adenovirus-mediated antisense expression inhibits colorectal cancer cell growth

Cancer Gene Therapy - Combination antisense oligodeoxyribonucleotide-radiation therapy evaluated

Cancer Prophylaxis - Cancer prevention by COX inhibitors aided by changes in gene expression

Cancer Risk Factors - Breast cancer risk is linked to a specific cyclooxygenase-2 genotype

Cancer Therapy - Findings describe new data in cancer therapy research

Cancer Therapy - Reports describe recent advances in cancer therapy research

Cancer Therapy - Trans-3,4'-bispyridinylethylenes proposed as potent inhibitors for cancer therapy

Cancer Vaccine - Allogeneic tumor cells expressing fusogenic membrane glycoproteins enable cancer immunotherapy

Cancer Vaccines - Recent findings illuminate research in cancer vaccines

Cancer Vaccines - Reports advance knowledge in cancer vaccines research

Cancer Vaccines - Researchers describe findings in cancer vaccines studies

Cancer Vaccines - Researchers report details of new studies and findings in the area of cancer vaccines

Cancer Vaccines - Studies advance knowledge in cancer vaccines research

Cardiology - Cardiomyocyte hypertrophy is exacerbated by selective loss of fine tuning G_q/11 signaling

Cardiology - Researchers' data advance cardiology research

Cardiology - Studies add new findings to cardiology body of knowledge

Cardiomyocytes - CTP:phosphocholine cytidylyltransferase activity correlates with sarcolemmal disruption in ischemia

Cardiomyocytes - In myocytes of post-MI rats, I_f modulation is depressed by beta₁ AR, enhanced by beta₃ AR

Cardiomyocytes - Study identifies interaction between C-terminal domain and membrane-binding domain of ankyrin-B

Cardiovascular Disease - Acute fatal Trypanosoma cruzi myocarditis is accompanied by changes in cell cycle proteins

Cervical Cancer - Cervical cancer linked to high-risk human papillomavirus types and viral load

Chlamydia Vaccine -  Chlamydia pneumoniae infection is prevented by IgA and T cell mucosal immune defenses

Chlamydia Vaccine -  Chlamydia trachomatis major outer membrane protein induces partial protection

Clinical Trials - CeraPedics initiates bone graft substitute P-15 Putty trial

Collaborations - Lilly and Biosite sign agreement to collaborate on clinical trial of severe sepsis drug

Collaborations - Target Discovery, medical school collaborate to develop prostate cancer clinical assays

Collaborations - Vertex, cystic fibrosis organization to collaborate to develop oral CF drug candidate

Colon Cancer - 2-Dodecylcyclobutanone proposed as possible risk factor for colon carcinogenesis

Colon Cancer - Colon cancer development inhibited by aspirin and NSAIDs

Colorectal Cancer - Reports advance knowledge in colorectal cancer research

Colorectal Cancer - Role of mismatch repair gene PMS2 in hereditary nonpolyposis colorectal cancer clarified

Crohn Disease - Crohn disease lamina propria lymphocytes utilize Flip to resist FAS-mediated apoptosis

Cystic Fibrosis - Researchers' work adds to cystic fibrosis body of knowledge

Cytomegalovirus - Asymptomatic congenital cytomegalovirus infection may be higher than currently estimated

DNA Immunization - Naked DNA immunization targeting survivin induces humoral and cellular immune responses

DNA Research - DNA strand breaks induce CAF-1 expression in quiescent human cells

DNA Research - Epigenetic gene silencing reverts cholesterol auxotrophy of NS0 cells

DNA Research - Sanguinarine and chelerythrine alter hepatoma cell CYP1A1 expression and activity

DNA Vaccine -  Brucella abortus DNA vaccine was evaluated by expression antigen fusion

DNA Vaccine -  Clonorchis sinensis fatty acid-binding protein induces an immune response

DNA Vaccine - Vaccination of mice with DNA vaccine induces Trichinella spiralis immune response

Dermatology - Atopic dermatitis lesions feature vascular endothelial growth factor

Developmental Biology - B-lineage precursors in bone marrow stimulated by a hybrid cytokine

Developmental Biology - Dentin phosphophoryn signaling involves activation of the smad pathway

Developmental Biology - Mesenchymal epimorphin is important for pancreatic duct morphogenesis

Diabetes Complications - Erectile function is restored to diabetic rats given angiogenic protein

Diabetes Complications - Islet cell autoimmunity is common in autoimmune endocrine patients in central Africa

Diabetes Pathogenesis - Aminoguanidine prevented blood antioxidant system impairment in diabetic rats

Diabetes Pathogenesis - Cannabinoid CB1 receptor activation induces glucose intolerance in rats

Diabetes Pathogenesis - Findings in diabetes pathogenesis provide new insights

Diabetes Pathogenesis - Increased ASP and complement C3 linked to diabetes and related lipid factors

Diabetes Pathogenesis - Recent findings in diabetes pathogenesis described

Diabetes Pathogenesis - mGLUT 9 splice variants are expressed in liver and kidney and are upregulated in diabetes

Diabetes Therapy - ACE inhibitor benefits in diabetes are due to protective action on pancreatic beta-cells

Diabetes Therapy - Researchers' work adds to diabetes therapy body of knowledge

Diagnostics - Angiogenesis, inflammation, and growth deregulation cytokines convey patient factors

Diagnostics - Cancers may be detected by the new biomarker YKL-40

Diagnostics - Method for genetic diagnosis of cancers developed

Diagnostics - Studies presented on accuracy, cost of imaging system for cervical cancer screening

Diet & Nutrition - S-adenosylmethionine with vitamins C and E protect against insulin resistance

Drug Development - Alcyopterosin A and illudalane derivatives evaluated as anticancer agents

Drug Development - Effect of 2-deoxyglucose (2-DG) on protein glycosylation investigated

Drug Development - Pyrrolo[2,1-c][1,4]benzodiazepine and indole conjugates evaluated as anticancer agents

Drug Development - Reports describe recent advances in drug development research

Drug Development - SARS coronavirus infection neutralized by monoclonal antibodies

Drug Development - Small peptides control epidermal growth factor receptor autophosphorylation

Drug Resistance - Cancer cells resist DNA-damaging agents with thymidine phosphorylase upregulation

Drug Toxicity - Cocaine-induced sodium channel block in cardiomyocytes is reversed by alpha₁ -acid glycoprotein

Endocrinology - 17-Beta-estradiol decreases p38 MAPK-mediated myocardial inflammation after acute ischemia

Endocrinology - Advanced ovarian cancer shows strong insulin-like growth factor II expression

Endocrinology - Breast cancer is marginally affected by estrogen's influence on tumor chemokine

Endometrial Cancer - Endometrial cancer cell proliferation is mediated by G protein-coupled receptor

Endometriosis - The pathology of endometriosis features leptin-mediated angiogenesis and inflammation