Enzymology
Vaccinia virus glycosylase forms heterodimeric processivity factor for viral DNA polymerase
Published in Proteomics Weekly, April 24th, 2006
"The vaccinia virus E9 protein, the catalytic subunit of the DNA polymerase holoenzyme, is inherently distributive under physiological conditions, although infected cells contain a highly processive form of the enzyme. The viral A20 protein was previously characterized as a stoichiometric component of the processivity factor, and an interaction between A20 and E9 was documented in vivo. A20 has been shown to interact with D4, the virally encoded uracil DNA glycosylase (UDG), by yeast-two hybrid and in vitro analysis," scientists...
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Source: Proteomics Weekly (2006-04-24)
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