Proteomics

Cell viability requires Repo-Man recruitment of protein phosphatase to chromatin

Published in Proteomics Weekly, April 24th, 2006

According to recently published research from Scotland, cell viability requires Repo-Man recruitment of protein phosphatase 1 (PP1) gamma to chromatin.

"PP1 is a ubiquitous Ser/Thr phosphatase regulating many cellular processes. PP1 alpha and -gamma are closely related isoforms with distinct localization patterns, shown here by time-lapse microscopy of stably expressed fluorescent protein fusions," wrote L. Trinkle-Mulcahy and colleagues, University of Dundee.

The investigators continued, "A pool of PP1 gamma is selectively loaded onto chromatin at anaphase. Using stable isotope labeling and proteomics, we identified a novel PP1 binding protein,...

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Source: Proteomics Weekly (2006-04-24)

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