Hepatitis B Virus

Recombinant GB virus B hepatitis virus with a p7 protein developed

Published in Proteomics Weekly, April 24th, 2006

Recent research from the United States has described the development of a recombinant GB virus B (GBV-B) hepatitis virus with a p7 protein.

"GBV-B, which infects tamarins, is the virus most closely related to hepatitis C virus (HCV). HCV has a protein (p7) that is believed to form an ion channel. It is critical for viability," wrote S. Takikawa and colleagues, U.S. National Institute of Allergy & Infectious Diseases.

They continued, "In vitro studies suggest that GBV-B has an analogous but larger protein (p13). We found that substitutions of the -1 and/or -3 residues of the putative cleavage sites (amino acid 613/614 and 732/733) abolished...

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Source: Proteomics Weekly (2006-04-24)

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