Acute Hepatitis

In acute hepatitis, glycoprotein oligosaccharides are modified by reactive oxygen species

Published in Proteomics Weekly, April 24th, 2006

According to research from Japan, in acute hepatitis, glycoprotein oligosaccharides are modified by reactive oxygen species (ROS).

"The Long-Evans Cinnamon (LEC) rat, an animal model of Wilson's disease, spontaneously develops hepatitis as the result of abnormal copper accumulation in liver. The findings of this study show that copper, hydrogen peroxide, and lipid peroxides accumulate to drastically high levels in LEC rat serum in acute hepatitis but not chronic hepatitis," wrote J. Yasuda and colleagues, Hyogo Medical University. "The effect of these ROS on oligosaccharides of glycoproteins in the LEC rat serum was examined."

"Lectin blot and lectin...

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Source: Proteomics Weekly (2006-04-24)

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