Proteomics Weekly

Apoptosis - Apoptosis is influenced by DNA damage-induced expression of p53

Malaria Vaccine -  Plasmodium falciparum merozoite surface protein-1₄₂ shows promise as vaccine candidate

Proteomics - Amyloid beta-peptide Lys-free derivative displays amyloidogenecity and pitrilysin sensitivity

Proteomics - Resistin binding peptide inhibits 3T3-L1 preadipocyte differentiation

Addiction Medicine - Opioid-induced regulation of gene expression occurs following mu-opioid receptor transfection

Allergy & Immunology - Allergen-induced peribronchial angiogenesis is inhibited by immunostimulatory DNA

Allergy & Immunology - B cell development is driven by transcription factors

Allergy & Immunology - Kupffer cells are activated early after blunt chest trauma

Alzheimer Disease - New findings from the United States and Switzerland in the area of Alzheimer disease described

Amyloidosis - Amyloidogenic fragment generated by serum amyloid A-activated mast cells

Amyotrophic Lateral Sclerosis - Discoveries should aid research into cause of ALS

Angiology - Cathepsin B proteolysis influences endothelial cell capillary-like tube formation

Angiology - Fibronectin synthesis in vascular smooth muscle cells requires protein kinase C delta

Angiology - Interleukin-1 beta, signaling of interleukin-1 in vascular wall modulates neointima formation in mice

Angiology - Low folate with mild hyperhomocysteinemia produced more arterial dysfunction than low folate alone

Angiology - Vascular smooth muscle cell proliferation is stimulated by urokinase plasminogen activator

Angiology - Vascular smooth muscle cell receptor-mediated calcium mobilization can be inhibited

Anthrax - Studies from the United States and India advance knowledge in anthrax research

Anthrax Vaccine - Recombinant Bacillus anthracis protective antigen protects against inhalational challenge

Apoptosis - Antianoikis is affected by up-regulated expression of osteoprotegerin, BCL-2, and IAP-1

Apoptosis - Glucocorticoid-induced apoptosis is mediated by thioredoxin-interacting protein

Apoptosis - Tumor suppressor function for p53 studied

Atherosclerosis - Modulation of cholesteryl ester transfer protein activity in atherogenesis is reviewed

Autoimmune Diseases - Post-streptococcal autoimmune CNS disease involves targeting of neuronal surface glycolytic enzymes

Autoimmune Diseases - Theiler virus infection induces astrocyte recognition by autoreactive T cells

Autoimmune Research - McGill describes gene in 20% of people of African descent that shuts down immune system

Bacteriology - Chimeric gene expression protects from lethal Escherichia coli infection

Biochemistry - Heparin octasaccharide is required for formation of FGF7-FGFR2IIIb complex

Bladder Cancer - Bladder cancer prognosis linked to enhanced expression of peroxiredoxin I and VI

Bovine Tuberculosis Vaccine - Mycobacterial vaccine is more potent than BCG against bovine tuberculosis

Brain Cancer - St. Jude researchers use biochemical pathways to identify correct drug for medulloblastoma

Breast Cancer - Breast cancer inhibited by calcitonin

Breast Cancer - Breast cancer survivin expression predicts clinical outcome

Breast Cancer - Findings from Germany, Japan and Ireland describe new data in breast cancer research

Breast Cancer - RANKL regulates cancer cell migration and bone metastasis

Breast Cancer - Recent studies from the United Kingdom, United States and Austria add new data to breast cancer research

Breast Cancer Vaccine - Breast cancer DNA vaccine efficacy is improved by beta-hCG C-terminal peptide boost

Breast Cancer Vaccine - Breast cancer vaccine plasmid DNA delivery systems were evaluated

Burn Care - Burn wound healing and angiogenesis are improved by recombinant erythropoietin

Business Update - Australian Proteome Analysis to adopt Nonlinear Dynamics' SameSpots approach

Cancer Gene Therapy - Osteosarcoma treated by adenovirus-mediated p53 gene therapy

Cancer Gene Therapy - Paclitaxel-induced apoptosis in lung cancer cells is enhanced by FHIT protein

Cancer Gene Therapy - Squamous cell carcinoma is inhibited by cationized gelatin delivery of siRNA

Cancer Gene Therapy - Tumor cell motility is modulated by MAP4K4 promigratory kinase

Cancer Research - Findings from South Africa and Japan advance knowledge in cancer research

Cancer Research - Researchers from Austria and the United States report details of new studies and findings in the area of cancer

Cancer Therapy - Cell adhesion and motility are influenced by integrin alpha 2-mediated ERK and calpain activation

Cancer Therapy - Dimeric cinnamaldehydes synthesized as potent antitumor agents

Cancer Therapy - Stanford scientists identify protein involved in fast-spreading cancers

Cancer Therapy - VEGF-C/Flt-4 axis promotes invasion and metastasis of cancer cells

Cancer Treatment - Findings from the United States and United Kingdom in cancer treatment provide new insights

Cancer Treatment - New findings from the United States, People's Republic of China and France in the area of cancer treatment detailed

Cancer Treatment - New findings in cancer treatment described from Netherlands and Japan

Cancer Treatment - Reports from Denmark, Japan and Canada add new data to cancer treatment research

Cancer Treatment - Reports from the United States advance knowledge in cancer treatment research

Cancer Treatment - Researchers from Netherlands, United States and Austria publish new studies and findings in the area of cancer treatment

Cancer Treatment - Researchers from the United States and Canada report details of new studies and findings in the area of cancer treatment

Cancer Treatment - Researchers' findings from Germany, Taiwan and the United States advance cancer treatment research

Cancer Treatment - Studies from Australia, Germany and the United States describe new findings in cancer treatment research

Cancer Treatment - Studies from Italy and the United States add new findings to cancer treatment body of knowledge

Cancer Vaccine - Control of regulatory T cells and cancer immunotherapy are focus of review

Cancer Vaccine - CpG ODNs induce immunity against a TERT-derived modified cryptic MHC class I-restricted epitope

Cancer Vaccine - Interleukin-expressing tumor membrane vesicles induce T cell proliferation

Cancer Vaccine - MHC class II T helper epitopes for WT1 tumor antigen may aid vaccine development

Cancer Vaccine - Polypeptide-based cancer vaccine's organization is optimized for immunogenicity

Cancer Vaccine - Tumor cells' growth and invasion are reduced by anti-sphingosine-1-phosphate antibody

Carcinogenesis - Anti-proliferative effect of COX inhibitors appears independent of COX-2 inhibition

Carcinogenesis - Carcinogenesis linked to generation of mutator mutants

Cardiology - Inherited conduction system abnormalities are one group of diseases, many genes

Cardiology - Reports from Germany, the South Korea and Sweden add new data to cardiology research

Cardiology - Research from Japan and Italy in cardiology provides new insights

Cardiology - Research from the United States in cardiology provides new insights

Cardiology - Researchers from the People's Republic of China, Italy and France report details of new studies and findings in the area of cardiology

Cardiology - Researchers from the United States and Germany report recent findings in cardiology

Cardiology - Researchers' work from France, the Czech Republic and Denmark adds to cardiology body of knowledge

Cardiology - Studies from Spain, Australia and the South Korea describe new findings in cardiology research

Cardiology - Studies from the United States and the Netherlands add new findings to cardiology body of knowledge

Cardiovascular Disease - Smoking delivers cadmium to the body which deregulates transcription, damages vascular endothelium

Cardiovascular Research - Data show addition of a bile acid sequestrant to statin therapy reduces median hs-CRP levels

Cardiovascular Research - Eplerenone cardioprotective mechanisms may be partly mediated by stimulating eNOS through Akt

Cardiovascular Research - New drug could reduce tissue damage after heart attack

Cardiovascular Risk Factors - C-reactive protein and neopterin levels may indicate cardiovascular risk in overweight

Cell Differentiation - Osteoblast differentiation is inhibited by lymphocyte enhancer-binding factor 1 (Lef1)

Cell Growth - Hepatocyte contact inhibition is regulated by growth factor-phosphatase association

Chlamydia - Recent findings in chlamydia described by researchers from the United States

Cholera Vaccine - Cholera vaccine candidate IEM108 resists CTX Phi infection

Clinical Trials - Jerini completes randomization of last patient in phase 3 trial of angioedema treatment

Clinical Trials - Lorus announces down regulation of GTI-2040 molecular target in breast cancer clinical study

Collaborations - Digene announces agreement with Asuragen, Inc. for cystic fibrosis screening products

Colon Cancer - ATM and BRCA1 expression may be related to survival in colorectal cancer

Colon Cancer - Colon cancer resection does not decrease plasma TIMP-1 levels postoperatively

Colorectal Cancer - Colorectal cancer apoptosis enhanced by synergism between violacein and 5-fluorouracil

Colorectal Cancer - Colorectal cancer c-fes protein-Tyr kinase functions in growth suppression

Colorectal Cancer - Colorectal cancer linked to expression of caveolin-1

Colorectal Cancer - Colorectal carcinoma overexpressed lysosomal enzymes are involved in neuronal ceroid lipofuscinosis

Colorectal Cancer - Findings from Denmark, Japan and Israel advance knowledge in colorectal cancer research

Colorectal Cancer - Research from the United States and Japan add new data to colorectal cancer body of knowledge

Cytomegalovirus - Cytomegalovirus antagonist inhibits signal transducer and activator of transcription signaling

DNA - Findings from the United States and the Netherlands in DNA provide new insights

Dengue Fever - Researchers from the United States and India describe findings in dengue fever studies

Developmental Biology - Maternal imprinting depends on oocyte growth

Diabetes - Recent findings from the United States and India illuminate research in diabetes

Diabetes - Recent findings from the United States and Israel illuminate research in diabetes

Diabetes - Reports from Italy, the United Kingdom and Germany add new data to diabetes research

Diabetes - Reports from the United States and Japan advance knowledge in diabetes research

Diabetes - Research from Netherlands, United States and Hungary in diabetes provides new insights

Diabetes - Researchers from the United States and Italy detail new studies and findings in the area of diabetes

Diabetes - Studies from Brazil, Italy and India describe new findings in diabetes research

Diabetes - Studies from Israel, Germany and the United States describe new findings in diabetes research

Diabetes Epidemiology - Agouti-related protein promoter variant appears to be linked to decreased diabetes risk

Diabetes Genetics - Diabetic rat proximal tubular cell osteopontin gene expression upregulation revealed

Diabetes Pathogenesis - PTEN deletion in beta cells leads to high islet mass and resistance to STZ-induced diabetes

Diabetes Therapy - Diabetes gene therapy is possible by injection of lentivirus containing insulin gene

Diagnostics - Reports from Japan, Germany and Netherlands describe recent advances in diagnostics research

Drug Delivery - Targeted drug delivery achieved using a hemoglobin-ribavirin conjugate

Drug Delivery - Tumor-derived microvesicles carry and deliver tumor cell surface determinants and mRNA to monocytes

Drug Development - Monoclonal antibodies against Nipah virus developed

Drug Resistance - Sbarro Institute researcher develops antimicrobial peptide to fight resistant bacteria

Drug Safety - Medical journal literature failed to guide drug usage in the case of cyclooxygenase-2 inhibitors

Endocrinology - Mineralocorticoid receptor is involved in regulation of hepatic glucose production genes

Entamoeba Histolytica - Blockage of Entamoeba histolytica cysteine proteases inhibits colonic mucus degradation

Epilepsy - Targeting ongoing caspase-dependent apoptosis signaling in TLE has therapeutic potential

Equine Herpesvirus Vaccine - CTL and IFN-gamma synthesis after equine herpesvirus vaccination are characterized

Esophageal Cancer - Esophageal cancer epidermal growth factor receptor targeted by erlotinib

Finance - Hercules provides $15 million in financing to Sirtris Pharmaceuticals

Finance - Sirtris Pharmaceuticals secures $37 million in new equity placement, venture debt financing

Gastric Cancer - Gastric cancer tumor stage linked to accumulation of DNA methylation

Gastric Cancer - Gastric carcinomas linked to distribution of p53 mutations

Genetics - Reports from the United States advance knowledge in genetics research

Genetics - Researchers' work from the United Kingdom, Japan and United States adds to genetics body of knowledge

Genetics & Genomics - Bone sialoprotein gene transcription is suppressed by chlorpromazine

Genetics & Genomics - Coding for arthropods - what's so special about insects and spiders?

Glioblastoma - Glioblastoma cell thermosensitivity is increased by trichostatin A

HIV Research - HIV-1 replication: Cells knocked-out for LEDGF/p75 and/or HRP2 useful genetic tools

HIV/AIDS - Findings from the United States and Australia in HIV/AIDS provide new insights

HIV/AIDS - Findings from the United States in HIV/AIDS provide new insights

HIV/AIDS - Reports from the United States, United Kingdom and Australia describe recent advances in HIV/AIDS research

HIV/AIDS - Researchers from the United States and Japan report recent findings in HIV/AIDS

HIV/AIDS - Studies from the United States add new findings to HIV/AIDS body of knowledge

HIV/AIDS Pathogenesis - HIV and SIV p6gag tolerant to small in-frame deletions downstream of late domain

HIV/AIDS Pathogenesis - HIV progression not conclusively associated with perforin gene polymorphism

HIV/AIDS Pathogenesis - HIV-1 gag binding protein annexin 2 essential for viral assembly in monocyte-derived macrophages

HIV/AIDS Pathogenesis - HIV-1 gp120 enhances giant depolarizing potentials via CXCR4 in neonatal hippocampus

HIV/AIDS Pathogenesis - HIV-1 Nef hydrophobic binding surface critical for association with Pak2

HIV/AIDS Pathogenesis - HIV-1 superinfected cells show increased mortality

HIV/AIDS Pathogenesis - HIV-1 Vif recognizes APOBEC3G and APOBEC3F by different mechanisms

HIV/AIDS Prognostic Indicator - Higher HIV viral load associated with mannose-binding lectin gene polymorphism

HIV/AIDS Vaccine - HIV clade C immunization by DNA prime/protein boost was safe and immunogenic in mice

HIV/AIDS Vaccine - HIV-1 control is affected by escape mutations in p24 Gag

HIV/AIDS Vaccine - HIV-1 subtype C vaccine candidate for India has been developed

HIV/AIDS Vaccine - HIV-1 Tat protein plus lipopeptide adjuvant elicited systemic and mucosal immune responses

Head & Neck Cancer - Reports from Finland, Slovenia and Italy describe recent advances in head & neck cancer research