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Lung Cancer

Favorable lung cancer prognosis linked to increased maspin gene expression

Published in Proteomics Weekly, May 22nd, 2006

Favorable non-small cell lung cancer (NSCLC) prognosis could be predicted by heightened maspin gene expression.

"Maspin is a member of the serpin (serine protease inhibitor) superfamily, and some experimental studies revealed a potential tumor suppressor activity of maspin. To reveal clinical significance of maspin status in NSCLC, we quantitatively evaluated maspin gene expression in lung primary tumors cut from a total of 55 resected NSCLC patients," scientists writing in the journal Lung Cancer reported.

"Maspin expression in squamous cell carcinoma (Sq) was significantly higher than that in adenocarcinoma (Ad, p=.011). Five-year overall...

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