Multiple Sclerosis
Multiple sclerosis deimination of myelin protein exposes an immunodominant epitope
Published in Proteomics Weekly, May 22nd, 2006
"The degradation of myelin in the CNS is the hallmark of multiple sclerosis. Reduction in the net positive charge of MBP, through deimination, correlates strongly with disease severity and may mediate myelin instability and loss of compaction," wrote A.A. Musse and colleagues, University of Guelph.
"Using Cys scanning, spin labeling, EPR spectroscopy, and site-specific proteolysis, we show that in the membrane-bound state the primary immunodominant epitope, V83-T92, of the less cationic recombinant murine MBP C8 mimic...
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Source: Proteomics Weekly (2006-05-22)
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