Cardiomyocytes

During simulated ischemia, Bax translocates to mitochondria of heart cells

Published in Proteomics Weekly, May 22nd, 2006

Bax translocation to mitochondria is an early step in ischemia, and it occurs in response to activation of p38 mitogen-activated protein kinase (MAPK) downstream of AMP-activated protein kinase (AMPK).

Researchers in England report, "The cytosolic protein Bax plays a key role in apoptosis by migrating to mitochondria and releasing pro-apoptotic proteins from the mitochondrial intermembrane space."

"The present study investigates the movement of Bax in isolated rat neonatal cardiomyocytes subjected to simulated ischemia (minus glucose, plus cyanide), using green fluorescent protein-tagged Bax as a means of imaging Bax movements," wrote M. Capano and...

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Source: Proteomics Weekly (2006-05-22)

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