Allergy & Immunology

T cell factors are required for collagen type I-mediated activation of ERK/MAP kinase

Published in Proteomics Weekly, May 22nd, 2006

According to a study from Canada, T cell factors are required for collagen type I-mediated activation of ERK/MAP kinase.

"Growing evidence indicates that interactions of T cells with extracellular matrix through beta 1 integrins are important for the regulation of T cell-mediated immune responses and diseases. In this regard, we have recently demonstrated that collagen 1 (Coll 1) through alpha 2 beta 1 integrin inhibited Fas-induced apoptosis of T cells by activating a protein phosphatase 2A (PP2A)-dependent ERK/MAP Kinase pathway," wrote N. Chetoui and colleagues, University of Quebec.

"As survival of T cells is critical for their functions, we...

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Source: Proteomics Weekly (2006-05-22)

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