Ischemia
Ischemia/reperfusion induces caspase-3 mediated proteolytic cleavage of MEKK1
Published in Proteomics Weekly, July 31st, 2006
According to a study from the United States, "Myocardial ischemia/reperfusion (IR) induces myocyte apoptosis, and the pro-apoptotic/tumor suppressor protein p53 may contribute to this process. However, the signaling mechanism by which IR induces p53 activation remains largely unknown."
D.C. Zebrowski and colleagues at University of Medicine & Dentistry of New Jersey wrote, "We show that MEKK1 undergoes proteolytic cleavage in a caspase-3 dependent manner in both in vivo and in vitro models of ischemic injury....
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Source: Proteomics Weekly (2006-07-31)
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