Published in Proteomics Weekly, August 7th, 2006
Investigators writing in the Journal of Biological Chemistry report, "Human hearts with end-stage failure and fibrosis have macrophage accumulation and elevated plasminogen activator activity. However, the mechanisms that link macrophage accumulation and plasminogen activator activity with cardiac fibrosis are unclear."
"We previously reported that mice with macrophage-targeted overexpression of urokinase plasminogen activator (SR-uPA+/0 mice) develop cardiac macrophage accumulation by 5...
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