Portal Hypertension
Liver lymph and blood vessel architecture changes in response to angiopoietin-1
Published in Proteomics Weekly, August 21st, 2006
Researchers in Canada conducted a study "to investigate the possible role of the angiopoietins in vessel remodeling. [They] overexpressed one of the angiopoietins, Ang1, in the hepatocytes of mice by means of the conditional binary transgenic system. Animals were examined by Doppler ultrasound, and dissected livers were analyzed by immunohistochemical staining."
"Double transgenic mice presented with enlarged spleens and kidneys, enlarged, disorganized blood vessels located near the surface of the liver, sprouting, dilation, and disorganization of liver...
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Source: Proteomics Weekly (2006-08-21)
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