Angiology

Venous thrombosis risk increased by hemostatic protein nonsense polymorphism

Published in Proteomics Weekly, August 21st, 2006

According to recently published research from Spain, a nonsense polymorphism in the protein Z-dependent protease inhibitor (ZPI) increases the risk for venous thrombosis.

"The protein ZPI is a hemostatic serpin with anticoagulant activity. As for antithrombin, deficiency of ZPI could have relevant thrombotic consequences," wrote J. Corral and colleagues, University of Murcia.

"We have studied 6 genetic modifications affecting the ZPI gene, identifying 5 haplotypes. Haplotype H5 is featured by a stop codon at position 67.

"The relevance of these genetic modifications and haplotypes in venous thrombosis was evaluated in a...

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Source: Proteomics Weekly (2006-08-21)

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