Leukemia
Research from Australia, Japan and the United Kingdom add new data to leukemia body of knowledge
Published in Proteomics Weekly, August 21st, 2006
Study 1: Scientists have identified the key LMO2-binding determinants on Ldb1.
According to researchers in Australia, "The overexpression of LIM-only protein 2 (LMO2) in T-cells, as a result of chromosomal translocations, retroviral insertion during gene therapy, or in transgenic mice models, leads to the onset of T-cell leukemias. LMO2 comprises two protein-binding LIM domains that allow LMO2 to interact with multiple protein partners, including LIM domain-binding protein 1 (Ldb1, also known as CLIM2 and NLI), an essential cofactor for LMO proteins....
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Source: Proteomics Weekly (2006-08-21)
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