Cardiomyocytes
Rat cardiomyocyte over-expression of Kv1.5 shortens action potential duration
Published in Proteomics Weekly, August 21st, 2006
Investigators writing in the journal Biochemical and Biophysical Research Communications report, "Genetically abnormal action potential duration (APD) can be a cause of arrhythmias that include long and short QT interval syndrome. The aim of this study was to evaluate the arrhythmogenic effect of short QT syndrome induced by the over-expression of Kv1.5 in rats."
"From Sprague-Dawley rats on fetal days 18-19, cardiomyocytes were excised and cultured with and without transfection with the Kv1.5 gene using an...
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Source: Proteomics Weekly (2006-08-21)
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