Neuroscience

Corticotropin-releasing factor receptor expression involves neurokinin receptor

Published in Proteomics Weekly, October 23rd, 2006

Substance P (SP) induces expression of the corticotropin-releasing factor receptor 1 (CRF1) by activation of the neurokinin-1 receptor (NK-1-R).

According to a report from Germany, "The neuropeptide SP has been found to be possibly involved in the etiology of affective and anxiety disorders. However, the molecular mechanisms underlying this involvement are still poorly understood.

"In this study, we used macroarrays to investigate the differential gene expression profile induced by SP, particularly of genes which have been shown to be involved in the pathophysiology of affective disorders," wrote M. Hamke and colleagues of the University of Freiburg....

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Source: Proteomics Weekly (2006-10-23)

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