Published in Proteomics Weekly, October 23rd, 2006
"Historically, most studies attribute p53 function to the transactivation of target genes. That p53 can selectively repress genes to affect a cellular response is less widely appreciated," wrote K.B. Spurgers and colleagues, M.D. Anderson Cancer Center.
They continued, "Available evidence suggests that repression is important for p53-induced apoptosis and cell cycle arrest. To better establish the scope of p53-repressed target genes and the cellular processes they may affect, a global...
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