Colon Cancer

Scientists at Sapporo Medical University, First Department of Internal Medicine publish new data on colon cancer

Published in Proteomics Weekly, December 11th, 2006

Scientists discuss in "2-methoxyestradiol, an endogenous mammalian metabolite, radiosensitizes colon carcinoma cells through c-Jun NH2-terminal kinase activation" new findings in colon cancer. "2-Methoxyestradiol (2ME), an estrogen metabolite, induces apoptosis in various cell types. We investigated whether 2ME pretreatment can radiosensitize colon adenocarcinoma cells," scientists in Sapporo, Japan report.

"Radiosensitizing effects of 2ME were evaluated by cell death, clonogenic assay, nuclear fragmentation, and tumor progression of xenografts. Ionizing radiation-induced DNA damage was evaluated by histone H2AX phosphorylation and its foci. The c-Jun NH2-terminal...

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Source: Proteomics Weekly (2006-12-11)

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