Colon Cancer Therapy

Data on colon cancer therapy discussed by researchers at Tzu Chi University, Institute of Pharmacology and Toxicology

Published in Proteomics Weekly, January 1st, 2007

A report, "Opposing securin and p53 protein expression in the oxaliplatin-induced cytotoxicity of human colorectal cancer cells," is newly published data in Toxicology Letters. According to recent research from Hualien, Taiwan, "Oxaliplatin, a clinical anticancer drug, has been used to treat colorectal cancer. Securin and p53 have been shown to regulate the cell cycle arrest and apoptosis."

"However, roles of securin and p53 on the oxaliplatin-induced cytotoxicity in human colorectal cancer cells remain unclear. Treatment with 1-10 microM oxaliplatin for 24 h induced the cell death, growth inhibition, and cell cycle arrest in RKO colorectal carcinoma cells. The...

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Source: Proteomics Weekly (2007-01-01)

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