Fusion Proteins
Scientists at Memorial Sloan-Kettering Cancer Center target fusion proteins
Published in Proteomics Weekly, January 8th, 2007
Research findings, "Enforced expression of NUP98-HOXA9 in human CD34(+) cells enhances stem cell proliferation," are discussed in a new report. According to recent research from the United States, "The t(7;11)(p15;p15) translocation, observed in acute myelogenous leukemia and myelodysplastic syndrome, generates a chimeric gene where the 5' portion of the sequence encoding the human nucleoporin NUP98 protein is fused to the 3' region of HOXA9. Here, we show that retroviral-mediated enforced expression of the NUP98-HOXA9 fusion protein in cord blood-derived CD34(+) cells confers a proliferative advantage in both cytokine-stimulated suspension cultures and stromal coculture."
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Source: Proteomics Weekly (2007-01-08)
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