Rheumatology
Study results from Imperial College London, Rheumatology Division in the area of rheumatology published
Published in Proteomics Weekly, January 8th, 2007
New investigation results, "Cell surface collagenolysis requires homodimerization of the membrane-bound collagenase MT1-MMP," are detailed in a study published in Molecular Biology of the Cell. According to recent research from London, the United Kingdom, "Pericellular degradation of interstitial collagens is a crucial event for cells to migrate through the dense connective tissue matrices, where collagens exist as insoluble fibers. A key proteinase that participates in this process is considered to be membrane-type 1 matrix metalloproteinase (MT1-MMP or MMP-14), but little is known about the mechanism by which it cleaves the insoluble collagen."
"Here we report that...
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Source: Proteomics Weekly (2007-01-08)
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